A Muroyama, S Uehara, S Yatsushiro, N Echigo, R … - Diabetes, 2004 - Am Diabetes Assoc Many metabolic factors affect the secretion of insulin from β-cells and glucagon from α-cells of
the islets of Langerhans to regulate blood glucose. Somatostatin from δ-cells, considered a local
inhibitor of islet function, reduces insulin and glucagon secretion by activating ... Cited by 9 - Related articles - BL Direct - All 7 versions
S Uehara, A Muroyama, N Echigo, R Morimoto, M … - Diabetes, 2004 - Am Diabetes Assoc In islets of Langerhans, l-glutamate is stored in glucagon-containing secretory granules of
α-cells and cosecreted with glucagon under low-glucose conditions. The l-glutamate triggers
secretion of γ-aminobutyric acid (GABA) from β-cells, which in turn inhibits glucagon ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►cell.com Y Moriyama, M Hayashi - Trends in pharmacological sciences, 2003 - Elsevier Increasing evidence suggests that the excitatory neurotransmitter -glutamate functions as a modulator
in the islet of Langerhans, an endocrine organ involved in blood glucose homeostasis. The islet
is equipped with all the elements required for -glutamate-mediated transmission, and it ... Cited by 21 - Related articles - All 8 versions
S Uehara, SK Jung, R Morimoto, S Arioka, … - Journal of …, 2006 - interscience.wiley.com Vesicular glutamate transporter (VGLUT) is responsible for the vesicular storage of
l-glutamate, and plays an essential role in glutamate-mediated intercellular signal transmission
in the CNS and in some neuroendocrine cells. Intestinal L cells are the ... Cited by 6 - Related articles - BL Direct - All 5 versions
M Hayashi, T Itabashi, Y Moriyama - Neuroscience letters, 1999 - Elsevier In mammals, -aspartate is present in various neuroendocrine cells, being especially abundant
in pinealocytes. Although -aspartate is suggested to be involved in some neuroendocrine
function, little is known about its origins as well as its physiological roles. In the present ... Cited by 5 - Related articles - All 4 versions
- ►diabetesjournals.org M Hayashi, M Otsuka, R Morimoto, A Muroyama, S … - Diabetes, 2003 - Am Diabetes Assoc Islets of Langerhans contain γ-aminobutyrate (GABA) and may use it as an intercellular
transmitter. In β-cells, GABA is stored in synaptic-like microvesicles and secreted through Ca
2+ -dependent exocytosis. Vesicular inhibitory amino acid transporter (VIAAT), which is ... Cited by 13 - Related articles - BL Direct - All 5 versions
- ►jhc.org M Hayashi, R Morimoto, A Yamamoto, Y … - … of Histochemistry and …, 2003 - Histochemical Soc L-Glutamate is an excitatory chemical transmitter that plays an essential role in neuronal
plasticity, behavior, learning, and memory in the central nervous system (Foster and Fagg 1984
Down ; Mayer and Westbrook 1987 Down ). To use L-glutamate as a signaling molecule, ... Cited by 28 - Related articles - BL Direct - All 3 versions
S Ishio, H Yamada, CM Craft, Y Moriyama - Brain research, 1999 - Elsevier Rat pinealocytes use -glutamate as a modulator for melatonin synthesis. Upon binding of -glutamate
to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of
cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity ... Cited by 6 - Related articles - All 5 versions
Y Akagi, A Hashigasako, P Degenaar, S … - Journal of …, 2003 - Jpn Biochemical Soc This paper describes a method for imaging the endogenous release of glutamate from cerebral
neurons. This method is based on the reactions of glutamate oxidase and peroxidase, and on
the detection of hydrogen peroxide by a fluorescent substrate of peroxidase. Glutamate ... Cited by 7 - Related articles - BL Direct - All 5 versions
Y Moriyama, H Yamada, M Hayashi, T Oda, A … - Neuroscience letters, 1998 - Elsevier -aspartate-containing fraction was evaporated to dryness in vacuo, and the resultant residue
was dissolved in 3% acetate in methanol. Then, aliquots (20 μl) were analyzed by HPLC on a
Sumichiral OA-2500 (R) column. Isocratic elution was performed with 4 mM citric acid in ... Cited by 8 - Related articles - All 4 versions
