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Scholar Results 1 - 10 of about 101 related to Brussee: Direct insulin signaling of neurons reverses diabetic neuropathy. (0.08 sec) 

Direct insulin signaling of neurons reverses diabetic neuropathy

- diabetesjournals.org
V Brussee, FA Cunningham, DW Zochodne - Diabetes, 2004 - Am Diabetes Assoc
Diabetic polyneuropathy is the most common acquired diffuse disorder of the peripheral nervous
system. It is generally assumed that insulin benefits human and experimental diabetic neuropathy
indirectly by lowering glucose levels. Insulin also provides potent direct support of ...
Cited by 66 - Related articles - BL Direct - All 5 versions

Near nerve local insulin prevents conduction slowing in experimental diabetes


A Singhal, C Cheng, H Sun, DW Zochodne - Brain research, 1997 - Elsevier
BRAIN RESEARCH ELSEVIER Brain Research 763 (1997) 209-214 Research report Near nerve
local insulin prevents conduction slowing in experimental diabetes Ash Singhal, Chu
Cheng, Hong Sun, Douglas W. Zochodne * Department of Clinical Neurosciences and ...
Cited by 43 - Related articles - All 4 versions

Expression and localization of insulin receptor in rat dorsal root ganglion and …


K Sugimoto, Y Murakawa, AAF … - Journal of the Peripheral …, 2002 - interscience.wiley.com
Abstract The expression and localization of the insulin receptor (IR) was examined in rat dorsal
root ganglia (DRG) and spinal cord using Western blotting, in situ hybridization and
immunocytochemistry. Western blotting showed that the molecular weight of the IR β ...
Cited by 47 - Related articles - BL Direct - All 3 versions

Insulin prevents depolarization of the mitochondrial inner membrane in sensory …

- diabetesjournals.org
TJ Huang, SA Price, L Chilton, NA Calcutt, DR … - Diabetes, 2003 - Am Diabetes Assoc
Mitochondrial dysfunction has been proposed as a mediator of neurodegeneration in diabetes
complications. The aim of this study was to determine whether deficits in insulin-dependent neurotrophic
support contributed to depolarization of the mitochondrial membrane in sensory neurons ...
Cited by 56 - Related articles - BL Direct - All 5 versions

Does diabetes target ganglion neurones?: Progressive sensory neurone …

- oxfordjournals.org
DW Zochodne, VMK Verge, C Cheng, H Sun, J … - Brain, 2001 - Oxford Univ Press
Targeting of dorsal root ganglia by diabetes could account for the selective sensory abnormalities
that patients with early diabetic polyneuropathy develop. In this work, we addressed survival,
phenotype and gene expression in sensory neurones in lumbar dorsal root ganglia in a ...
Cited by 56 - Related articles - BL Direct - All 5 versions

C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes


H Kamiya, W Zhang, AAF Sima - Annals of neurology, 2004 - interscience.wiley.com
It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ...
Cited by 35 - Related articles - BL Direct - All 3 versions

Remote neurotrophic support of epidermal nerve fibres in experimental diabetes


C Toth, V Brussee, DW Zochodne - Diabetologia, 2006 - Springer
Abstract Aims/hypothesis: The support of distal regen- erating axons and epidermal nerve fibres
through growth factor delivery may depend on the site of delivery. While low-dose systemic insulin
provides trophic support for regenerating axons or axons from diabetic animals, its ...
Cited by 25 - Related articles - BL Direct - All 3 versions

Molecular alterations underlie nodal and paranodal degeneration in type 1 diabetic …


AAF Sima, W Zhang, ZG Li, Y Murakawa, CR Pierson - Diabetes, 2004 - Am Diabetes Assoc
To explore the molecular abnormalities underlying the degeneration of the node of Ranvier,
a characteristic aberration of type 1 diabetic neuropathy, we examined in type 1 BB/Wor and
type 2 BBZDR/Wor rats changes in expression of key molecules that make up the nodal ...
Cited by 41 - Related articles - BL Direct - All 4 versions

Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic …


CR Pierson, W Zhang, Y Murakawa, AAF … - … of Neuropathology & …, 2003 - journals.lww.com
Abstract. Diabetic polyneuropathy (DPN) shows more severe functional and structural changes
in type 1 than in type 2 human and experimental diabetes. We have previously suggested that
these differences may be due to insulin and/or C-peptide deficiencies in type 1 diabetes. ...
Cited by 34 - Related articles - BL Direct - All 4 versions

Insulin as an in vivo growth factor


QG Xu, XQ Li, SA Kotecha, C Cheng, HS Sun, DW … - Experimental Neurology, 2004 - Elsevier
Insulin peptide has been identified to promote regeneration of axons in culture and in some in
vivo model systems. Such actions have been linked to direct actions of insulin, or to cross occupation
of closely linked IGF-1 receptors. In this work, we examined insulin support of peripheral ...
Cited by 17 - Related articles - All 3 versions


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