SA Price, S Agthong, AB Middlemas, DR Tomlinson - Diabetes, 2004 - Am Diabetes Assoc This study examined the role of p38 mitogen-activated protein (MAP) kinase in transducing high
glucose into deficits in nerve conduction velocity (NCV) that are characteristic of diabetic
neuropathy. p38 activation and NCV were measured in streptozocin-induced diabetic rats ... Cited by 45 - Related articles - BL Direct - All 8 versions
- ►inotekcorp.com [PDF] F Li, C Szabo, P Pacher, GJ Southan, OI Abatan, T … - Diabetologia, 2004 - Springer Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and high-energy
phosphates, activates protein kinase C, and affects gene expression in various tissues. This
study was designed to charac- terise the effects of the potent, orally active ... Cited by 38 - Related articles - BL Direct - All 11 versions
Z Song, DTW Fu, YS Chan, S Leung, SSM Chung, … - Molecular and Cellular …, 2003 - Elsevier To further understand the role of aldose reductase (AR) in the etiology of diabetic
neuropathy, we generated transgenic mice that overexpress AR specifically in the Schwann
cells under the control of the rat myelin protein zero (P 0 ) promoter. One of the transgenic ... Cited by 52 - Related articles - All 3 versions
NE Cameron, Z Tuck, L McCabe, MA Cotter - Diabetologia, 2001 - Springer Page 1. Oxidative stress contributes to the neural and vascu- lar complications of
diabetes [1, 2]. For nerve, antiox- idant protection is impaired; glutathione content
is diminished and lipid peroxidation markers are in- creased ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►fasebj.org T PURVES, A MIDDLEMAS, S AGTHONG, EB JUDE, … - The FASEB Journal, 2001 - FASEB The onset of diabetic neuropathy, a complication of diabetes mellitus, has been linked to poor
glycemic control. We tested the hypothesis that the mitogen-activated protein kinases
(MAPK) form transducers for the damaging effects of high glucose. In cultures of adult rat ... Cited by 104 - Related articles - BL Direct - All 6 versions
NA Calcutt, JD Freshwater, AP Mizisin - Diabetologia, 2004 - Springer Aims/hypothesis. Sensory neuropathy in diabetic pa- tients frequently presents itself as progressive
loss of thermal perception, while some patients describe con- current spontaneous pain, allodynia
or hyperalgesia. Diabetic rats develop thermal hypoalgesia and tactile allodynia by ... Cited by 48 - Related articles - BL Direct - All 7 versions
- ►anabolicfitness.net [PDF] NE Cameron, AM Jack, MA Cotter - Free Radical Biology and Medicine, 2001 - Elsevier Oxidative stress contributes to the vascular and neurological complications of diabetes
mellitus. The aim was to evaluate the effects of treatment with the radical scavenger and transition
metal chelator, α-lipoic acid, on endothelium-dependent relaxation of the mesenteric ... Cited by 38 - Related articles - BL Direct - All 8 versions
- ►nih.gov NA Calcutt, KL Allendoerfer, AP Mizisin, A … - Journal of Clinical …, 2003 - Am Soc Clin Investig Hedgehog proteins modulate development and patterning of the embryonic nervous system.
As expression of desert hedgehog and the hedgehog receptor, patched-1, persist in the postnatal
and adult peripheral nerves, the hedgehog pathway may have a role in maturation and ... Cited by 40 - Related articles - BL Direct - All 7 versions
- ►fasebj.org [PDF] IG Obrosova, CV Huysen, L Fathallah, X Cao, DA … - The FASEB Journal, 2001 - FASEB The FASEB Journal express article 10.1096/fj.01-0603fje. Published online November 14,
2001. ... An aldose reductase inhibitor reverses early diabetes- ... Irina G. Obrosova*, Carol
Van Huysen*, Lamia Fathallah*, Xianghui Cao*, Douglas A. Greene*, Martin J. Stevens* , † Cited by 93 - Related articles - BL Direct - All 5 versions
S Agthong, DR Tomlinson - ANNALS-NEW YORK ACADEMY OF …, 2002 - interscience.wiley.com Abstract: Diabetes is known to activate MAP kinase p38 in sensory neurons in both rats and
patients. In vitro, activation of p38 in sensory neurons by combined glucose and oxidant stress
causes cell damage or death. Consequently we tested the hypothesis that inhibition of ... Cited by 17 - Related articles - BL Direct - All 4 versions
