- ►pubget.com [PDF] BJ Barratt, F Payne, CE Lowe, R Hermann, BC Healy, … - Diabetes, 2004 - Am Diabetes Assoc Type 1 diabetes susceptibility at the IDDM2 locus was previously mapped to a variable number
tandem repeat (VNTR) 5' of the insulin gene (INS). However, the observation of associated markers
outside a 4.1-kb interval, previously considered to define the limits of IDDM2 association, ... Cited by 111 - Related articles - BL Direct - All 6 versions
D Smyth, JD Cooper, JE Collins, JM Heward, JA … - Diabetes, 2004 - Am Diabetes Assoc In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive
irrefutable linkage and association results have been rare to date. Recently, it has been reported
that a single nucleotide polymorphism (SNP), 1858C>T, in the gene PTPN22, encoding ... Cited by 244 - Related articles - BL Direct - All 5 versions
- ►nih.gov A Vella, JD Cooper, CE Lowe, N Walker, S Nutland, … - The American Journal of …, 2005 - Elsevier Despite hundreds of association studies, few have been consistently replicated (Dahlman et
al. 2002; Hirschhorn et al. 2003; Ioannidis et al. 2003; Lohmueller et al. 2003). In type 1 diabetes
(T1D [MIM 222100]), only four loci have been identified and successfully replicated: the ... Cited by 137 - Related articles - All 6 versions
- ►oxfordjournals.org F Cucca, R Lampis, M Congia, E Angius, S … - Human Molecular …, 2001 - Oxford Univ Press In human type 1 diabetes (T1D) and in its murine model, the major histocompatibility complex
(MHC) class II molecules, human leukocyte antigens (HLA)-DQ and -DR and their murine
orthologues, IA and IE, are the major genetic determinants. In this report, we have ranked ... Cited by 102 - Related articles - BL Direct - All 7 versions
DJ Smyth, JD Cooper, R Bailey, S Field, O Burren, LJ … - Nature genetics, 2006 - nature.com 2 Clinic of Diabetes, Institute of Diabetes, Nutrition and Metabolic Diseases 'N.Paulescu', Bucharest
79811, Romania. ... 3 Department of Paediatrics, University of Cambridge, Addenbrooke's
Hospital, Cambridge CB2 2XY, UK. ... 4 Department of Medical Genetics, Queen's ... Cited by 190 - Related articles - BL Direct - All 6 versions
JDH Stead, ME Hurles, AJ Jeffreys - Genome research, 2003 - genome.cshlp.org The insulin minisatellite (INS VNTR) has been intensively analyzed due to its associations with
diseases including diabetes. We have previously used patterns of variant repeat distribution
in the minisatellite to demonstrate that genetic diversity is unusually great in Africans ... Cited by 25 - Related articles - BL Direct - All 15 versions
- ►diabetesjournals.org HQ Qu, A Montpetit, B Ge, TJ Hudson, C … - Diabetes, 2007 - Am Diabetes Assoc A novel type 1 diabetes locus was mapped to the interleukin-2 receptor α gene (IL2RA) on chromosome
10p15.1, encoding an important modulator of immunity. The aim of the current study was to confirm
the association of IL2RA with type 1 diabetes and to attempt further mapping of the ... Cited by 38 - Related articles - BL Direct - All 5 versions
CE Lowe, JD Cooper, T Brusko, NM Walker, DJ Smyth, … - Nature - diabetes.ufl.edu Genome-wide association studies are now identifying disease-associated chromosome
regions. However, even after convincing replication, the localization of the causal variant(s) requires
comprehensive resequencing, extensive genotyping and statistical analyses in large ... Cited by 99 - Related articles - View as HTML - BL Direct - All 10 versions
