- ►diabetesjournals.org PJ Kaisaki, M Delépine, PY Woon, L Sebag-Montefiore, … - Diabetes, 2004 - Am Diabetes Assoc Type II SH2 domain–containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important
role in the control of insulin sensitivity. INPPL1 mutations affecting gene function have been found
in rat models of type 2 diabetes and hypertension and in type 2 diabetic patients. We ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org E Marion, PJ Kaisaki, V Pouillon, C Gueydan, JC Levy, … - Diabetes, 2002 - Am Diabetes Assoc Genetic susceptibility to type 2 diabetes involves many genes, most of which are still
unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and
sensitivity in vivo and is thus a good candidate gene. Here we report the presence of ... Cited by 58 - Related articles - BL Direct - All 6 versions
- ►endojournals.org S Kagawa, T Sasaoka, S Yaguchi, H Ishihara, H … - Journal of Clinical …, 2005 - Endocrine Soc TYPE 2 (NONINSULIN DEPENDENT) diabetes mellitus is a disorder characterized by insulin
resistance in the target tissue of insulin with insufficient insulin secretion in pancreatic ß-cells
(1). The molecular mechanisms underlying the insulin resistance in insulin signals ... Cited by 10 - Related articles - All 4 versions
T Sasaoka, H Hori, T Wada, M Ishiki, T Haruta, H … - Diabetologia, 2001 - Springer Activation of the PI3-kinase is known to be extreme- ly important for exerting various metabolic
actions of insulin [1ą3].PI(3,4,5)P3 produced by the activated PI3-kinase is thought to function
as a key lipid second messenger for signalling to further downstream mole- cules [4ą6]. ... Cited by 52 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org H Hori, T Sasaoka, H Ishihara, T Wada, S Murakami, M … - Diabetes, 2002 - Am Diabetes Assoc SH-2-containing inositol 5′-phosphatase 2 (SHIP-2) is a physiologically important lipid phosphatase
that functions to hydrolyze phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P3 to PI(3,4)P2
in the negative regulation of insulin signaling. We investigated whether SHIP-2 is ... Cited by 54 - Related articles - BL Direct - All 4 versions
MW Sleeman, KE Wortley, KMV Lai, LC Gowen, J … - Nature medicine, 2005 - nature.com Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol 5-phosphatase
2), was previously reported to induce severe insulin sensitivity, leading to early postnatal
death. In the previous study, the targeting construct left the first eighteen exons encoding ... Cited by 73 - Related articles - All 6 versions
K Fukui, T Wada, S Kagawa, K Nagira, M Ikubo, H … - Diabetes, 2005 - Am Diabetes Assoc We investigated the role of hepatic SH2-containing inositol 5′-phosphatase 2 (SHIP2) in glucose
metabolism in mice. Adenoviral vectors encoding wild-type SHIP2 (WT-SHIP2) and a
dominant-negative SHIP2 (ΔIP-SHIP2) were injected via the tail vein into db/+m and ... Cited by 24 - Related articles - All 5 versions
- ►nih.gov T Wada, T Sasaoka, M Funaki, H Hori, S … - Molecular and Cellular …, 2001 - Am Soc Microbiol Phosphatidylinositol (PI) 3-kinase plays an important role in various metabolic actions of insulin
including glucose uptake and glycogen synthesis. Although PI 3-kinase primarily functions as
a lipid kinase which preferentially phosphorylates the D-3 position of phospholipids, the ... Cited by 108 - Related articles - BL Direct - All 5 versions
T Sasaoka, T Wada, K Fukui, S Murakami, H … - Journal of Biological …, 2004 - ASBMB SH2-containing inositol phosphatase 2 (SHIP2) is a physiologically important negative regulator
of insulin signaling by hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI 3,4,5-trisphosphate
in the target tissues of insulin. Targeted disruption of the SHIP2 gene in mice resulted in ... Cited by 41 - Related articles - BL Direct - All 4 versions
CIM Panhuysen, LA Cupples, PWF Wilson, AG Herbert, … - Diabetologia, 2003 - Springer Aims/hypothesis. Hyperinsulinaemia and insulin resis- tance usually precede clinical hyperglycaemia
and Type 2 diabetes. Thus, plasma insulin concentrations and insulin resistance are important
quantitative traits associated with risk of Type 2 diabetes, and represent key measures for ... Cited by 43 - Related articles - BL Direct - All 3 versions
