MD'Adamo, L Perego, M Cardellini, MA Marini, S … - Diabetes, 2004 - Am Diabetes Assoc Uncoupling protein (UCP)-2 is a member of the mitochondrial inner membrane carriers that uncouple
pro-ton entry in the mitochondrial matrix from ATP synthesis. The −866G/A polymorphism in the
UCP2 gene, which enhances its transcriptional activity, was associated with enhanced ... Cited by 64 - Related articles - BL Direct - All 5 versions
- ►endojournals.org A Bulotta, O Ludovico, A Coco, R Di Paola, A … - Journal of Clinical …, 2005 - Endocrine Soc Uncoupling protein-2 (UCP2) regulates insulin secretion and may play an important role in linking
obesity to type 2 diabetes (T2D). Previous studies of the role of the UCP2 promoter –866G/A
single nucleotide polymorphisms (SNP) in T2D have given opposite results. We tested ... Cited by 33 - Related articles - All 5 versions
F Krempler, H Esterbauer, R Weitgasser, C … - Diabetes, 2002 - Am Diabetes Assoc Obesity is frequently associated with type 2 diabetes. We previously observed an association
of a functional G/A polymorphism in the uncoupling protein 2 (UCP2) promoter with obesity. The
wild-type G allele was associated with reduced adipose tissue mRNA expression in vivo, ... Cited by 95 - Related articles - BL Direct - All 4 versions
M Sasahara, M Nishi, H Kawashima, K Ueda, S … - Diabetes, 2004 - Am Diabetes Assoc Common uncoupling protein 2 (UCP2) promoter polymorphism −866G/A is reported to be associated
with its expression in adipose tissue and the risk of obesity in Caucasians. On the other
hand, several studies suggested that UCP2 expression in β-cells is an important ... Cited by 60 - Related articles - BL Direct - All 4 versions
G Sesti, M Cardellini, MA Marini, S Frontoni, MD'Adamo … - Diabetes, 2003 - Am Diabetes Assoc It was reported that the common −866G/A polymorphism in the promoter of the human uncoupling
protein-2 (UCP2) gene, which enhances its trascriptional activity, is associated with increased
mRNA levels in human adipocytes and reduced risk of obesity. Studies in knockout mice ... Cited by 87 - Related articles - BL Direct - All 4 versions
- ►physiology.org H Wang, WS Chu, T Lu, SJ Hasstedt, PA … - American Journal of …, 2004 - Am Physiological Soc The onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance, and impaired
-cell function. Uncoupling protein-2 (UCP2) is a widely expressed inner mitochondrial membrane
protein. Common polymorphisms of the UCP2 gene have been implicated in diabetes, in ... Cited by 63 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Le Fur, C Le Stunff, C Dos Santos, P Bougnères - Diabetes, 2004 - Am Diabetes Assoc Uncoupling protein (UCP) 2 is a member of the mitochondrial transporter superfamily that uncouples
proton entry in the mitochondrial matrix from ATP synthesis. Although its physiological role remains
to be established, UCP2 is considered a candidate gene for association with energy ... Cited by 39 - Related articles - BL Direct - All 5 versions
LT Dalgaard, G Andersen, LH Larsen, TIA Sørensen, T … - Obesity, 2003 - nature.com Research Methods and Procedures: The human UCP2 promoter was characterized by reporter
gene analysis in cell lines derived from skeletal muscle, white adipose tissue, and embryonic
tissue. We analyzed the core promoter for polymorphisms in 60 obese subjects. A ... Cited by 23 - Related articles - BL Direct - All 3 versions
AF Reis, D Dubois-Laforgue, C Bellanné-Chantelot, … - Molecular Genetics and …, 2004 - Elsevier AG/A single nucleotide polymorphism (SNP) in the position −866 of the UCP2 promoter modulates
UCP2 expression in adipose tissue and pancreatic β-cell, and is associated with variations of
body mass index (BMI) and insulin secretion in nondiabetic subjects. We investigated ... Cited by 16 - Related articles - All 3 versions
