- ►diabetesjournals.org L Raimondi, P De Paoli, E Mannucci, G Lonardo, L … - Diabetes, 2004 - Am Diabetes Assoc Recent evidence suggests that blockade of the renin-angiotensin system ameliorates
diabetes-induced cardiac dysfunction, but the mechanisms involved in this process remain
elusive. We investigated the effect of treatment with an angiotensin II receptor blocker, ... Cited by 20 - Related articles - BL Direct - All 5 versions
N Yaras, B Turan - Molecular and cellular biochemistry, 2005 - Springer Sarcolemmal Na + –Ca2+ exchange plays a central role in ion transport of the myocardium and
the current carried with it contributes to the late phase of the action potential (AP) besides the
contribution of outward K ... + -currents; transient outward current, Ito and steady-state Cited by 9 - Related articles - All 5 versions
X Liu, H Suzuki, R Sethi, PS Tappia, N … - ANNALS-NEW …, 2006 - interscience.wiley.com Abstract: Although the defects in the sarcolemma (SL) and sarcoplasmic reticulum (SR) membranes
are known to be associated with cardiac dysfunction in chronic diabetes, very little information
regarding the mechanisms of these membrane abnormalities is available in the literature. ... Cited by 8 - Related articles - BL Direct - All 6 versions
S Ozdemir, M Ugur, H Gürdal, B Turan - Archives of Biochemistry and …, 2005 - Elsevier We investigated the effect of treatment with an angiotensin II receptor blocker,
candesartan-cilexetil, on the mechanical and electrophysiological properties of cardiomyocytes
isolated from streptozotocin-induced diabetic (STZ) rats. Contractile activity and ... Cited by 13 - Related articles - All 3 versions
O Bilim, Y Takeishi, T Kitahara, T Arimoto, T … - Cardiovascular …, 2008 - cardiab.com We examined transgenic mice with cardiac-specific overexpression of DGKζ (DGKζ-TG) compared
to wild type (WT) mice in streptozotocin-induced (STZ, 150 mg/kg) diabetic and nondiabetic
conditions. After 8 weeks, decreases in heart weight and heart weight/body weight ratio in ... Cited by 3 - Related articles - Cached - All 10 versions
- ►physiology.org N Yaras, A Bilginoglu, G Vassort, B … - American Journal of …, 2007 - Am Physiological Soc Stimulation of local renin-angiotensin system and increased levels of oxidants characterize the
diabetic heart. Downregulation of ANG II type 1 receptors (AT 1 ) and enhancement in PKC activity
in the heart point out the role of AT 1 blockers in diabetes. The purpose of this study was ... Cited by 14 - Related articles - BL Direct - All 5 versions
D Qin, B Huang, L Deng, H El-Adawi, K Ganguly, … - … and Biophysical Research …, 2001 - Elsevier Type I diabetic cardiomyopathy has consistently been shown to be associated with decrease
of repolarising K + currents, but the mechanisms responsible for the decrease are not well
defined. We investigated the streptozotocin (STZ) rat model of type I diabetes. We utilized ... Cited by 48 - Related articles - BL Direct - All 5 versions
J Chiu, H Farhangkhoee, BY Xu, S Chen, B George … - Journal of Molecular and …, 2008 - Elsevier Diabetic cardiomyopathy is characterized by structural alterations such as cardiomyocyte
hypertrophy, necrosis and focal fibrosis. Hyperglycemia-induced oxidative damage may play
an important role in this pathogenetic process. Recent studies have shown that poly (ADP- ... Cited by 5 - Related articles - All 17 versions
FC Howarth, R Al-Sharhan, A Al-Hammadi, MA … - Molecular and cellular …, 2007 - Springer Abstract In vivo biotelemetry studies have demon- strated that heart rate (HR) is progressively
and rap- idly reduced after administration of streptozotocin (STZ) and that the reduction in HR
can be partially normalized with insulin replacement. Reductions in HR have also been ... Cited by 4 - Related articles - BL Direct - All 6 versions
- ►nih.gov SV Pandit, WR Giles, SS Demir - Biophysical journal, 2003 - Elsevier Our mathematical model of the rat ventricular myocyte (Pandit et al., 2001) was utilized to explore
the ionic mechanism(s) that underlie the altered electrophysiological characteristics associated
with the short-term model of streptozotocin-induced, type-I diabetes. The simulations ... Cited by 31 - Related articles - BL Direct - All 8 versions
