LE Fridlyand, LH Philipson - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS)
production, and oxidative stress in pancreatic β-cells may be tightly linked
processes. Here we suggest that the same pathways used in the activation of ... Cited by 54 - Related articles - BL Direct - All 5 versions
LE Fridlyand, LH Philipson - apoptosis, 1942 - Am Diabetes Assoc Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS)
production, and oxidative stress in pancreatic -cells may be tightly linked
processes. Here we suggest that the same pathways used in the activation of ... Related articles
VP Bindokas, A Kuznetsov, S Sreenan, KS … - Journal of Biological Chemistry, 2003 - ASBMB Oxygen free radicals have been implicated in β-cell dysfunction and apoptosis
associated with type 1 and type 2 diabetes mellitus. The roles of free radicals
in diabetes have thus far been defined indirectly by monitoring oxidative ... Cited by 73 - Related articles - BL Direct - All 4 versions
LE Fridlyand, LH Philipson - Nutrition and diabetes: pathophysiology and …, 2006 - books.google.com 17 The Nutrient Paradox: Oxidative Stress in Pancreatic B-Cells Leonid E.
Fridlyand, Ph. D. and Louis H. Philipson, MD, Ph. D. CONTENTS I. Introduction
303 II. Glucose Uptake and ATP/ADP Regulation 304 III. Connection of ROS ... Related articles
H Takahashi, POT Tran, E LeRoy, JS Harmon … - Journal of Biological Chemistry, 2004 - ASBMB D-Glyceraldehyde (D-GLYC) is usually considered to be a stimulator of insulin
secretion but theoretically can also form reactive oxygen species (ROS), which
can inhibit beta cell function. We examined the time- and concentration- ... Cited by 24 - Related articles - BL Direct - All 4 versions
LE Fridlyand, LH Philipson - Current Diabetes Reviews, 2006 - ingentaconnect.com Abstract: Insulin resistance (IRe) and a failure of insulin secretion are the
major features of the early pathophysiology of type-2 diabetes mellitus (T2D)
but the etiology is still not well understood. We suggest that: 1. The ... Cited by 15 - Related articles - BL Direct - All 2 versions
S Lortz, M Tiedge - Free Radical Biology and Medicine, 2003 - Elsevier Insulin-producing cells show very low activity levels of the cytoprotective
enzymes catalase, glutathione peroxidase, and superoxide dismutase. This weak
antioxidative defense status has been considered a major feature of the ... Cited by 37 - Related articles - All 4 versions
T Mandrup-Poulsen - Biochemical pharmacology, 2003 - Elsevier Failure of insulin producing pancreatic β-cells is a common characteristic of
type 1 (insulin-dependent) and type 2 (insulin non-dependent) diabetes mellitus.
Accumulating evidence suggests that programmed cell death (apoptosis) is ... Cited by 70 - Related articles - All 5 versions
- ►diabetesjournals.org E Gurgul, S Lortz, M Tiedge, A Jörns, S … - Diabetes, 2004 - Am Diabetes Assoc Insulin-producing cells are known for their extremely low antioxidant equipment
with hydrogen peroxide (H 2 O 2 )-inactivating enzymes. Therefore, catalase was
stably overexpressed in mitochondria and for comparison in the cytoplasmic ... Cited by 42 - Related articles - BL Direct - All 4 versions
LE Fridlyand, LH Philipson - Diabetes Obesity and Metabolism, 2006 - interscience.wiley.com The early stages of type 2 diabetes mellitus are characterized by the
development of insulin resistance (IRe) in muscle cells and adipocytes with the
concomitant loss of β-cell compensation. We have extensively reviewed the ... Cited by 45 - Related articles - BL Direct - All 4 versions
