- ►diabetesjournals.org KJ Mather, A Lteif, HO Steinberg, AD Baron - Diabetes, 2004 - Am Diabetes Assoc Endothelial dysfunction reflects an imbalance of vasodilators and
vasoconstrictors. Endogenous endothelin activity seems to be increased in human
obesity and type 2 diabetes, and cellular studies suggest that this factor ... Cited by 66 - Related articles - BL Direct - All 4 versions
KJ Mather, B Mirzamohammadi, A Lteif, HO … - Diabetes, 2002 - Am Diabetes Assoc Endothelium-dependent vasodilation is impaired in clinical states of insulin
resistance such as obesity and type 2 diabetes. Individuals who have
hyperinsulinemic insulin resistance have relatively elevated circulating ... Cited by 114 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org C Cardillo, U Campia, M Iantorno, JA Panza - Hypertension, 2004 - Am Heart Assoc Hypertensive patients have increased endothelin-1–dependent vasoconstrictor
tone. This abnormality, however, might not be uniformly present in all forms of
hypertension, as suggested by experimental studies showing that ... Cited by 62 - Related articles - BL Direct - All 8 versions
- ►ahajournals.org C Cardillo, CM Kilcoyne, RO Cannon III, JA … - Hypertension, 2000 - Am Heart Assoc Abstract—Endothelial release of nitric oxide (NO) contributes to the
regulation of vascular tone by inducing vascular relaxation. In addition, NO may
inhibit the synthesis and hemodynamic effects of endothelin-1 (ET-1), a ... Cited by 75 - Related articles - BL Direct - All 5 versions
AD Baron, M Tarshoby, G Hook, EN Lazaridis, … - Diabetes, 2000 - Am Diabetes Assoc Insulin and glucose delivery (muscle perfusion) can modulate insulin-mediated
glucose uptake. This study was undertaken to determine 1) to what extent insulin
sensitivity modulates the effect of perfusion on glucose uptake and 2) ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►physiology.org MA Potenza, FL Marasciulo, DM Chieppa, GS … - American Journal of Physiology- Heart and Circulatory …, 2005 - Am Physiological Soc Insulin stimulates production of NO in vascular endothelium via activation of
phosphatidylinositol (PI) 3-kinase, Akt, and endothelial NO synthase. We
hypothesized that insulin resistance may cause imbalance between ... Cited by 87 - Related articles - BL Direct - All 5 versions
A Lteif, P Vaishnava, AD Baron, KJ Mather - Diabetes, 2007 - Am Diabetes Assoc The normal action of insulin to vasodilate and redistribute blood flow in
support of skeletal muscle metabolism is impaired in insulin-resistant states.
Increased endogenous endothelin contributes to endothelial dysfunction in ... Cited by 22 - Related articles - BL Direct - All 6 versions
MA Vincent, D Dawson, ADH Clark, JR Lindner, … - Diabetes, 2002 - Am Diabetes Assoc Supraphysiological doses of insulin enhance total limb blood flow and recruit
capillaries in skeletal muscle. Whether these processes change in response to
physiological hyperinsulinemia is uncertain. To examine this, we infused ... Cited by 78 - Related articles - BL Direct - All 5 versions
- ►physiology.org EC Eringa, CDA Stehouwer, GP van Nieuw … - American Journal of Physiology- Heart and Circulatory …, 2004 - Am Physiological Soc Insulin exerts both NO-dependent vasodilator and endothelin-dependent
vasoconstrictor effects on skeletal muscle arterioles. The intracellular enzymes
1-phosphatidylinositol 3-kinase (PI3-kinase) and Akt have been shown to ... Cited by 38 - Related articles - BL Direct - All 5 versions
A Avogaro, G Toffolo, E Kiwanuka, SV De … - Diabetes, 2003 - ncbi.nlm.nih.gov Defective endothelium is a key event in the development of atherosclerosis in
diabetes: alteration of the L-arginine-nitric oxide (NO) pathway has been
suggested. We propose a modeling approach of the L-arginine-NO pathway in ... Cited by 25 - Related articles - BL Direct - All 2 versions
