S Cook, O Hugli, M Egli, B Ménard, S Thalmann, C … - Diabetes, 2004 - Am Diabetes Assoc Nitric oxide (NO) plays a major role in the regulation of cardiovascular and metabolic
homeostasis, as evidenced by insulin resistance and arterial hypertension in endothelial NO
synthase (eNOS) null mice. Extrapolation of these findings to humans is difficult, however, ... Cited by 43 - Related articles - BL Direct - All 4 versions
S Cook, O Hugli, M Egli, P Vollenweider, R Burcelin, P … - Swiss Medical Weekly, 2003 - smw.ch Aims/hypothesis: The metabolic syndrome comprises a clustering of cardiovascular risk fac-
tors but the underlying mechanism is not known. Mice with targeted disruption of endothelial
nitric oxide synthase (eNOS) are hypertensive and in- sulin resistant. We wondered, ... Cited by 52 - Related articles - View as HTML - BL Direct - All 4 versions
- ►ahajournals.org H Duplain, R Burcelin, C Sartori, S Cook, M Egli, M … - Circulation, 2001 - Am Heart Assoc Methods and Results— To study the role of eNOS in the control of the metabolic action of
insulin, we assessed insulin sensitivity in conscious mice with disruption of the gene encoding
for eNOS. eNOS -/- mice were hypertensive and had fasting hyperinsulinemia, ... Cited by 201 - Related articles - BL Direct - All 8 versions
RR Shankar, Y Wu, H Shen, JS Zhu, AD … - DIABETES-NEW …, 2000 - Am Diabetes Assoc Studies from our laboratory using acute pharmacologic blockade of nitric oxide synthase
(NOS) activity have suggested that nitric oxide (NO) has an important role in regulating carbohydrate
metabolism. We now report on insulin sensitivity in mice with targeted disruptions in ... Cited by 156 - Related articles - BL Direct - All 4 versions
LD Monti, C Barlassina, L Citterio, E Galluccio, C … - Diabetes, 2003 - Am Diabetes Assoc Endothelial nitric oxide synthase (eNOS) variants were previously demonstrated in cardiovascular
disease. To evaluate whether eNOS gene variants are associated with insulin resistance and
type 2 diabetes, we evaluated polymorphisms in Exon7 (E298D), intron 18 (IVS18 + ... Cited by 80 - Related articles - BL Direct - All 4 versions
K Ohtoshi, Y Yamasaki, S Gorogawa, R Hayaishi- … - Diabetologia, 2002 - Springer Aims/hypothesis. Endothelial derived nitric oxide syn- thase (eNOS) gene polymorphisms affect
eNOS activi- ty and are associated with abnormal vasomotility and impaired local blood flow.
A decrease in local blood flow has been reported to cause insulin resistance. The aim of ... Cited by 42 - Related articles - BL Direct - All 3 versions
- ►endojournals.org C Perrin, C Knauf, R Burcelin - Endocrinology, 2004 - Endocrine Soc The AMP-activated kinase has been proposed to be an important intracellular energy sensor
because the enzyme controls lipid and glucose oxidation. In the corresponding knockout
mice, insulin-stimulated muscle glycogen synthesis and glucose tolerance are reduced. ... Cited by 32 - Related articles - BL Direct - All 3 versions
C Cabou, PD Cani, G Campistron, C Knauf, C Mathieu, … - Diabetes, 2007 - Am Diabetes Assoc RESULTS —In normal mice, central insulin rapidly increased heart rate by 30% and more progressively
increased blood flow by 40%. In high-fat diet–fed mice, the cardiovascular effects of insulin were
blunted and associated with a 50% reduction of the total and phosphorylated eNOS ... Cited by 8 - Related articles - BL Direct - All 3 versions
QH Jin, T Kunitake, CP Chu, DL Qiu, K Kato, Y Ishizuka … - Brain research, 2003 - Elsevier The objective of this study was to elucidate the possible involvement of nitric oxide (NO) in the
cardiovascular responses induced by central salt loading. Direct perfusion of the hypothalamic
paraventricular nucleus (PVN) region with hypertonic saline (0.3 or 0.45 M) was ... Cited by 9 - Related articles - All 5 versions
