- ►diabetesjournals.org J Menne, JK Park, M Boehne, M Elger, C Lindschau, T … - Diabetes, 2004 - Am Diabetes Assoc Activation of protein kinase C (PKC) isoforms has been implicated in the pathogenesis of diabetic
nephropathy. We showed earlier that PKC-α is activated in the kidneys of hyperglycemic
animals. We now used PKC-α −/− mice to test the hypothesis that this PKC isoform ... Cited by 52 - Related articles - BL Direct - All 4 versions
V Thallas-Bonke, C Lindschau, B Rizkalla, LA Bach, G … - Diabetes, 2004 - Am Diabetes Assoc This study investigated the role of advanced glycation end products (AGEs) in mediating protein
kinase C (PKC) isoform expression in diabetic nephropathy. In vitro, vascular smooth muscle
cells incubated in a high-glucose (25-mmol/l) medium demonstrated translocation and ... Cited by 67 - Related articles - BL Direct - All 5 versions
N Kang, G Alexander, JK Park, C Maasch, I … - Kidney international, 1999 - nature.com The cellular effects of hyperglycemia are mediated by protein kinase C (PKC). However, PKC
consists of several distinct isoforms, and their contribution to the pathogenesis of diabetic complications
in different organs is not clear. We investigated the expression and translocation of PKC ... Cited by 85 - Related articles - BL Direct - All 5 versions
J Menne, M Meier, JK Park, M Boehne, T Kirsch, C … - Kidney international, 2006 - nature.com Albuminuria in diabetic nephropathy is due to endothelial dysfunction, a loss of negative charges
in the basement membrane, and changes a of the slit-membrane diaphragm composition. We
have recently shown that protein kinase C alpha (PKC )-deficient mice are protected ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►asnjournals.org IL PFAFF, HJ WAGNER, V VALLON - Journal of the American Society of …, 1999 - Am Soc Nephrol Abstract. Protein kinase C (PKC) significantly contributes to the control of renal function, but little
is known about the renal function or localization of PKC isoenzymes. Therefore, the localization
of PKC isoenzymes , ßI, and ßII was studied in rat kidney. Immunoblot analysis identified ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►physiology.org [PDF] S Redling, IL Pfaff, M Leitges, V … - American Journal of …, 2004 - Am Physiological Soc 38 articles, 19 of which you can access free at: This article cites http://ajprenal.physiology.org
/cgi/content/full/287/2/F289#BIBL ... 8 other HighWire hosted articles, the first 5 are: This article
has been cited by ... [PDF] [Full Text] [Abstract] , February 1, 2007; 56 (2): 346-354. ... Cited by 27 - Related articles - All 5 versions
- ►diabetesjournals.org A Flyvbjerg, F Dagnæs-Hansen, AS De Vriese, BF … - Diabetes, 2002 - Am Diabetes Assoc Diabetic nephropathy in type 2 diabetic patients is a frequent complication associated with increased
morbidity and mortality. Various growth factors and cytokines have been implicated in the pathogenesis
of diabetic kidney disease, including vascular endothelial growth factor (VEGF). To ... Cited by 180 - Related articles - BL Direct - All 4 versions
M Meier, GL King - Vascular Medicine, 2000 - vmj.sagepub.com Abstract: Vascular complications in diabetes mellitus are known to be associated with the
acti- vation of the protein kinase C (PKC) pathway through the de novo synthesis of diacylglycerol
(DAG) from glycolytic intermediates. Specific PKC isoforms, mainly the - and -isoforms, ... Cited by 76 - Related articles - BL Direct - All 4 versions
M Meier, JK Park, D Overheu, T Kirsch, C Lindschau, F … - Diabetes, 2007 - Am Diabetes Assoc The protein kinase C (PKC)-β isoform has been implicated to play a pivotal role in the development
of diabetic kidney disease. We tested this hypothesis by inducing diabetic nephropathy in
PKC-β–deficient (PKC-β −/− ) mice. We studied nondiabetic and streptozotocin-induced ... Cited by 17 - Related articles - BL Direct - All 6 versions
