HF Gu, S Efendic, S Nordman, CG Östenson, K Brismar … - Diabetes, 2004 - Am Diabetes Assoc Insulin-degrading enzyme (IDE) plays a principal role in the proteolysis of several peptides in
addition to insulin and is encoded by IDE, which resides in a region of chromosome 10q that is
linked to type 2 diabetes. Two ... Cited by 36 - Related articles - BL Direct - All 4 versions
S Karamohamed, S Demissie, J Volcjak, C Liu, N … - Diabetes, 2003 - Am Diabetes Assoc Linkage studies have mapped a susceptibility gene for type 2 diabetes to the long arm of chromosome
10, where we have previously identified a quantitative trait locus that affects fasting blood
glucose within the Framingham Heart ... Cited by 56 - Related articles - BL Direct - All 5 versions
CJ Groves, S Wiltshire, D Smedley, KR Owen, TM … - Diabetes, 2003 - Am Diabetes Assoc The gene for insulin-degrading enzyme (IDE) represents a strong positional and biological candidate
for type 2 diabetes susceptibility. IDE maps to chromosome 10q23.3, a region linked to diabetes in
several populations; the rat ... Cited by 40 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Florez, S Wiltshire, CM Agapakis, NP Burtt, PIW de … - Diabetes, 2006 - Am Diabetes Assoc The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene
IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and related
phenotypes. Due to the impact of ... Cited by 29 - Related articles - BL Direct - All 7 versions
SH Kwak, YM Cho, MK Moon, JH Kim, BL Park, HS … - Diabetes research and …, 2008 - Elsevier Insulin-degrading enzyme (IDE) is a metalloproteinase which degrades insulin and terminates its
action. Homologous deletion of IDE gene resulted in hyperinsulinemia and glucose intolerance in a
rat model of type 2 diabetes ... Cited by 5 - Related articles - All 14 versions
T Saric, D Müller, HJ Seitz, K Pavelic - Molecular and cellular endocrinology, 2003 - Elsevier Insulin-degrading enzyme (IDE) is a metalloprotease implicated in insulin degradation and suggested
to have a variety of additional functions, including the clearance of amyloid β peptides of
Alzheimer's disease. Little is ... Cited by 17 - Related articles - All 5 versions
A Sakai, H Ujike, K Nakata, Y Takehisa, T … - American Journal of …, 2004 - interscience.wiley.com Susceptibility to Alzheimer's disease (AD) is thought to be regulated by multiple genetic factors.
Recently, three independent studies have reported that loci on chromosome 10q are linked with AD,
and the insulin degrading enzyme ... Cited by 18 - Related articles - BL Direct - All 3 versions
- ►amjpathol.org W Farris, S Mansourian, MA Leissring, EA Eckman, L … - American Journal of …, 2004 - ASIP The causes of cerebral accumulation of amyloid ß-protein (Aß) in most cases of Alzheimer's disease
(AD) remain unknown. We recently found that homozygous deletion of the insulin-degrading enzyme
(IDE) gene in mice results in an ... Cited by 97 - Related articles - BL Direct - All 7 versions
JA Prince, L Feuk, HF Gu, B Johansson, M Gatz, … - Human …, 2003 - interscience.wiley.com Linkage studies have identified a large (>60-Mb) region on chromosome 10q that segregates with
Alzheimer Disease (AD). Within the region, the gene for insulin degrading enzyme (IDE) represents a
notable biological candidate given ... Cited by 65 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org H Fakhrai-Rad, A Nikoshkov, A Kamel, M … - Human Molecular …, 2000 - Oxford Univ Press Genetic analysis of the diabetic GK rat has revealed several diabetes susceptibility loci. Congenic
strains have been established for the major diabetes locus, Niddm1, by transfer of GK alleles onto
the genome of the normoglycemic ... Cited by 86 - Related articles - BL Direct - All 4 versions
