- ►diabetesjournals.org AL Cuesta-Muñoz, H Huopio, T Otonkoski, JM … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) is a glycolytic key enzyme that functions as a glucose sensor
in the pancreatic β-cell, where it governs glucose-stimulated insulin secretion
(GSIS). Heterozygous inactivating mutations in the glucokinase gene (GCK) ... Cited by 69 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org AL Gloyn, K Noordam, MAAP Willemsen, S … - Diabetes, 2003 - Am Diabetes Assoc Glucokinase (GCK) is a key regulatory enzyme in the pancreatic β-cell and
catalyzes the rate-limiting step for β-cell glucose metabolism. We report two
novel GCK mutations (T65I and W99R) that have arisen de novo in two ... Cited by 78 - Related articles - BL Direct - All 5 versions
HBT Christesen, BB Jacobsen, S Odili, C … - Diabetes, 2002 - Am Diabetes Assoc In this study, a second case of hyperinsulinemic hypoglycemia due to activation
of glucokinase is reported. The 14-year-old proband had a history of neonatal
hypoglycemia, treated with diazoxide. He was admitted with coma and ... Cited by 118 - Related articles - BL Direct - All 6 versions
D Zelent, H Najafi, S Odili, C Buettger, H Weik … - Biochemical Society Transactions, 2005 - bst.portlandpress.com The enzyme GK (glucokinase), which phosphorylates glucose to form glucose
6-phosphate, serves as the glucose sensor of insulin-producing b-cells. GK has
thermodynamic, kinetic, regulatory and molecular genetic characteristics ... Cited by 42 - Related articles - Cached - All 9 versions
- ►shouxi.net AL Gloyn, S Odili, D Zelent, C Buettger, HAJ … - Journal of Biological Chemistry, 2005 - ASBMB Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous
inactivating GCK mutations cause hyperglycemia, whereas activating mutations
cause hypoglycemia. We studied the GCK V62M mutation identified in two ... Cited by 31 - Related articles - All 7 versions
[CITATION] Glucokinase
GI Bell, A Cuesta-Munoz, FM Matschinsky - Encyclopedia of Molecular Medicine. New York, Wiley, 2002 Cited by 28 - Related articles
- ►endojournals.org AM Efanov, DG Barrett, MB Brenner, SL Briggs … - Endocrinology, 2005 - Endocrine Soc The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose
metabolism. We report here the effects of a novel glucokinase activator,
LY2121260. The activator enhanced GK activity via binding to the allosteric ... Cited by 55 - Related articles - BL Direct - All 5 versions
P Dunterf, A Swain, U Kammlotf, R Crowther, … - Glucokinase and glycemic diseases: from basics to …, 2004 - books.google.com Matschinsky FM, Magnuson MA (eds): Glucokinase and Glycemic Disease: From Basics
to Novel Therapeutics. Front Diabetes. Basel, Karger, 2004, vol 16, pp 145-154
Crystal Structure of Human Liver Glucokinase Bound to a Small Molecule ... Cited by 17 - Related articles - All 4 versions
- ►cell.com K Kamata, M Mitsuya, T Nishimura, J Eiki, Y … - Structure, 2004 - Elsevier Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a
sigmoidal saturation curve for its substrate, two properties that are important
for its playing the role of a glucose sensor in pancreas and liver. The ... Cited by 127 - Related articles - All 10 versions
J Grimsby, FM Matschinsky, JF Grippo - Glucokinase and Glycemic Disease: From Basics to … - books.google.com Fig. 3. Close-up of GKA binding site showing amino acid residues making direct
interactions with a GKA. Mutations in V62, M210 and M235 cause the MODY-2 pheno-
type whereas V455M, A456V and Y214A mutations increase the catalytic ... Cited by 21 - Related articles - BL Direct - All 3 versions
