- ►diabetesjournals.org CF Deacon - Diabetes, 2004 - Am Diabetes Assoc Glucagon-like peptide (GLP)-1 is an incretin hormone with potent glucose-dependent insulinotropic
and glucagonostatic actions, trophic effects on the pancreatic β-cells, and inhibitory effects on
gastrointestinal secretion and motility, which combine to lower plasma glucose and ... Cited by 155 - Related articles - BL Direct - All 5 versions
B Ahrén, R Gomis, E Standl, D Mills, A Schweizer - Diabetes Care, 2004 - Am Diabetes Assoc RESULTS—In patients randomized to LAF237, baseline HbA 1c averaged 7.7 ± 0.1% and decreased
at week 12 (Δ = −0.6 ± 0.1%), whereas HbA 1c did not change from a baseline of 7.9 ± 0.1%
in patients given placebo (between-group difference in ΔHbA 1c = −0.7 ± 0.1%, P < ... Cited by 313 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org KB Degn, CB Juhl, J Sturis, G Jakobsen, B Brock, V … - Diabetes, 2004 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1) is potentially a very attractive agent for treating type 2
diabetes. We explored the effect of short-term (1 week) treatment with a GLP-1 derivative, liraglutide
(NN2211), on 24-h dynamics in glycemia and circulating free fatty acids, islet cell ... Cited by 170 - Related articles - BL Direct - All 8 versions
- ►endojournals.org B Ahren, M Landin-Olsson, PA Jansson, M … - Journal of Clinical …, 2004 - Endocrine Soc The stimulation of insulin vs. inhibition of glucagon secretion in relation to the antidiabetic action
of glucagon-like peptide-1 (GLP-1) is not established. Here, the influence of a 4-wk increase
in circulating GLP-1 by inhibition of dipeptidyl peptidase-4 (DPP-4) on 24-h glucose and ... Cited by 331 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org DJ Drucker - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide
(GIP) exert important effects on β-cells to stimulate glucose-dependent insulin secretion. Both
peptides also regulate β-cell proliferation and cytoprotection. GLP-1, but not GIP, inhibits ... Cited by 284 - Related articles - All 13 versions
KB Degn, B Brock, CB Juhl, CB Djurhuus, J Grubert, D … - Diabetes, 2004 - Am Diabetes Assoc This study assessed whether glucose-dependent insulin secretion and overall counterregulatory
response are preserved during hypoglycemia in the presence of exenatide. Twelve healthy fasted
volunteers were randomized in a triple-blind crossover study to receive either intravenous ... Cited by 124 - Related articles - BL Direct - All 6 versions
SK Patel, RK Goyal, IS Anand, JS Shah, HU Patel, … - Indian Journal of …, 2006 - Medknow GLP-1 action is mediated by binding to a specific, seven-transmembrane G-protein coupled receptor
(GLP-1 receptor) that is coupled positively to the adenylyl cyclase (AC) system.[13],[14] Ligand
activation of the Ga subunit of the GLP-1 receptor stimulates AC, which leads to an ... Cited by 3 - Related articles - Cached - BL Direct - All 7 versions
CB Juhl, M Hollingdal, J Sturis, G Jakobsen, H Agersø, … - Diabetes, 2002 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1) is a potent glucose-lowering agent of potential interest for the
treatment of type 2 diabetes. To evaluate actions of NN2211, a long-acting GLP-1 derivative,
we examined 11 patients with type 2 diabetes, age 59 ± 7 years (mean ± SD), BMI 28.9 ± ... Cited by 175 - Related articles - BL Direct - All 6 versions
CF Deacon, B Ahrén, JJ Holst - eid, 2004 - informahealthcare.com Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) are of increasing interest to both diabetologists
and the pharmaceutical industry alike, as they may become established as the next member
of the oral antidiabetic class of therapeutic agents, designed to lower blood glucose and, ... Cited by 102 - Related articles - All 7 versions
DJ Drucker - eid, 2003 - informahealthcare.com Incretins are peptide hormones, exemplified by glucose-dependent insulino- tropic peptide and
glucagon-like peptide 1 that are released from the gut in response to nutrient ingestion and enhance
glucose-stimulated insulin secre- tion. Incretin action is terminated due to N-terminal ... Cited by 118 - Related articles - All 6 versions
