- ►diabetesjournals.org JR Bain, JC Schisler, K Takeuchi, CB … - Diabetes, 2004 - Am Diabetes Assoc Silencing gene expression by RNA interference (RNAi) can provide insight into
gene function but requires efficient delivery of small interfering RNAs (siRNAs)
into cells. Introduction of exogenous nucleic acids can be especially ... Cited by 52 - Related articles - BL Direct - All 5 versions
JC Schisler, PB Jensen, DG Taylor, TC … - Proceedings of the National Academy of Sciences of …, 2005 - National Acad Sciences We have previously described rat insulinoma INS-1-derived cell lines with robust
or poor glucose-stimulated insulin secretion (GSIS). In the current study, we
have further resolved these lines into three classes: class 1, glucose- ... Cited by 54 - Related articles - All 11 versions
MV Jensen, JW Joseph, O Ilkayeva, S … - Journal of Biological Chemistry, 2006 - ASBMB We have previously reported that glucose-stimulated insulin secretion (GSIS) is
tightly correlated with pyruvate carboxylase (PC)-catalyzed anaplerotic flux
into the tricarboxylic acid cycle and stimulation of pyruvate cycling ... Cited by 32 - Related articles - BL Direct - All 4 versions
A Boucher, D Lu, SC Burgess, S Telemaque- … - Journal of Biological Chemistry, 2004 - ASBMB Hyperlipidemia appears to play an integral role in loss of glucose-stimulated
insulin secretion (GSIS) in type 2 diabetes. This impairment can be simulated in
vitro by chronic culture of 832/13 insulinoma cells with high ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►jbc.org JW Joseph, ML Odegaard, SM Ronnebaum, SC … - Journal of Biological Chemistry, 2007 - ASBMB It has been proposed that de novo synthesis of long-chain acyl-CoA (LC-CoA) is a
signal for glucose-stimulated insulin secretion (GSIS). Key enzymes involved in
synthesis of fatty acids from glucose include ATP-citrate lyase (CL) and ... Cited by 15 - Related articles - All 4 versions
A Khan, ZC Ling, BR Landau - Journal of Biological Chemistry, 1996 - ASBMB Pyruvate has been estimated to enter the citric acid cycle in islets by
carboxylation to the same extent or more than by decarboxylation. Those
estimates were made assuming the dimethyl esters of [1,4- 14 C]succinate ... Cited by 54 - Related articles - BL Direct - All 4 versions
MJ MacDonald - Archives of biochemistry and biophysics, 1993 - ncbi.nlm.nih.gov 1: Arch Biochem Biophys. 1993 Sep;305(2):205-14. Estimates of glycolysis,
pyruvate (de)carboxylation, pentose phosphate pathway, and ... Cited by 55 - Related articles - BL Direct - All 2 versions
SM Ronnebaum, O Ilkayeva, SC Burgess, JW … - Journal of Biological Chemistry, 2006 - ASBMB Glucose-stimulated insulin secretion (GSIS) from pancreatic islet β-cells is
central to control of mammalian fuel homeostasis. Glucose metabolism mediates
GSIS in part via ATP-regulated K + (K ATP ) channels, but multiple lines of ... Cited by 41 - Related articles - All 5 versions
JW Joseph, MV Jensen, O Ilkayeva, F … - Journal of Biological Chemistry, 2006 - ASBMB Glucose-stimulated insulin secretion (GSIS) is mediated in part by glucose
metabolism-driven increases in ATP/ADP ratio, but by-products of mitochondrial
glucose metabolism also play an important role. Here we investigate the ... Cited by 28 - Related articles - All 7 versions
- ►diabetesjournals.org [PDF] HE Hohmeier, H Mulder, G Chen, R Henkel- … - Diabetes, 2000 - Am Diabetes Assoc The biochemical mechanisms involved in regulation of insulin secretion are not
completely understood. The rat INS-1 cell line has been used to gain insight in
this area because it secretes insulin in response to glucose con- ... Cited by 209 - Related articles - BL Direct - All 5 versions
