- ►diabetesjournals.org BA Spurlin, SY Park, AK Nevins, JK Kim, DC Thurmond - Diabetes, 2004 - Am Diabetes Assoc Insulin-stimulated translocation of GLUT4 vesicles from an intracellular compartment to the plasma
membrane in 3T3L1 adipocytes is mediated through a syntaxin 4 (Syn4)- and Munc18c-dependent
mechanism. To investigate the impact of increasing Syn4 protein abundance on glucose ... Cited by 19 - Related articles - BL Direct - All 5 versions
T Saito, S Okada, E Yamada, K Ohshima, H … - Journal of Biological …, 2003 - ASBMB Although syntaxin 1 is generally thought to function as the primary target-N-ethylmaleimide-sensitive
factor attachment protein receptor required for pancreatic cell insulin secretion, we have observed
that overexpression of a dominant-interfering syntaxin 4 mutant (syntaxin 4/ TM) ... Cited by 22 - Related articles - BL Direct - All 4 versions
E Oh, BA Spurlin, JE Pessin, DC Thurmond - Diabetes, 2005 - Am Diabetes Assoc The disruption of Munc18c binding to syntaxin 4 impairs insulin-stimulated GLUT4 vesicle translocation
in 3T3L1 adipocytes. To investigate the physiological function and requirement for Munc18c
in the regulation of GLUT4 translocation and glucose homeostasis in vivo, we used ... Cited by 34 - Related articles - All 6 versions
- ►diabetesjournals.org BA Spurlin, RM Thomas, AK Nevins, HJ Kim, YJ Kim, … - Diabetes, 2003 - Am Diabetes Assoc To investigate the physiological effects of modulating the abundance of Munc18c or syntaxin
4 (Syn4) proteins on the regulation of glucose homeostasis in vivo, we generated
tetracycline-repressible transgenic mice that overexpress either Munc18c or Syn4 ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BA Spurlin, DC Thurmond - Molecular Endocrinology, 2006 - Endocrine Soc Numerous overexpression studies have recently implicated Syntaxin 4 as an effector of insulin
secretion, although its requirement in insulin granule exocytosis is unknown. To address
this, islets from Syntaxin 4 heterozygous (–/+) knockout mice were isolated and compared ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►jbc.org AK Nevins, DC Thurmond - Journal of Biological Chemistry, 2005 - ASBMB In pancreatic beta cells, insulin granule exocytosis is regulated by SNARE (soluble
N-ethylmaleimide-sensitive factor attachment protein receptor protein (SNAP) receptor)
proteins, and this is coupled to cortical F-actin reorganization via the Rho family GTPase ... Cited by 37 - Related articles - All 5 versions
- ►jbc.org E Oh, DC Thurmond - Journal of Biological Chemistry, 2006 - ASBMB Stimulus-induced tyrosine phosphorylation of Munc18c was investigated as a potential regulatory
mechanism by which the Munc18c-Syntaxin 4 complex can be dissociated in response to divergent
stimuli in multiple cell types. Use of [ 32 P]orthophosphate incorporation, pervanadate ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►nih.gov C Yang, KJ Coker, JK Kim, S Mora, DC … - Journal of Clinical …, 2001 - Am Soc Clin Investig To investigate the physiological function of syntaxin 4 in the regulation of GLUT4 vesicle
trafficking, we used homologous recombination to generate syntaxin 4–knockout mice. Homozygotic
disruption of the syntaxin 4 gene results in early embryonic lethality, whereas ... Cited by 63 - Related articles - BL Direct - All 9 versions
D C. Thurmond, Jeffrey E. Pessin - Molecular membrane …, 2001 - Informa Pharma Science Page 1. Molecular machinery involved in the insulin-regulated fusion of GLUT4-
containing vesicles with the plasma membrane (Review) Debbie C. Thurmond{ and
Jeffrey E. Pessin{* {Indiana University School of Medicine, Department ... Cited by 62 - Related articles - BL Direct - All 6 versions
DC Thurmond, JE Pessin - The EMBO Journal, 2000 - pubmedcentral.nih.gov To examine the temporal relationship between pre- and post-docking events, we generated a
Munc18c temperature-sensitive mutant (Munc18c/TS) by substitution of arginine 240 with a lysine
residue. At the permissive temperature (23°C), overexpression of both the wild type ( ... Cited by 40 - Related articles - BL Direct - All 5 versions
