- ►diabetesjournals.org E Gurgul, S Lortz, M Tiedge, A Jörns, S … - Diabetes, 2004 - Am Diabetes Assoc Insulin-producing cells are known for their extremely low antioxidant equipment
with hydrogen peroxide (H 2 O 2 )-inactivating enzymes. Therefore, catalase was
stably overexpressed in mitochondria and for comparison in the cytoplasmic ... Cited by 42 - Related articles - BL Direct - All 4 versions
S Lortz, E Gurgul-Convey, S Lenzen, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Free radicals generated in mi- tochondria play a
crucial role in the toxic effects of cy- tokines upon insulin-producing cells.
This study therefore investigated the role of manganese superoxide ... Cited by 11 - Related articles - BL Direct - All 3 versions
AK Azevedo-Martins, S Lortz, S Lenzen, R Curi … - Diabetes, 2003 - Am Diabetes Assoc Proinflammatory cytokines (interleukin-1ß [IL-1ß], tumor necrosis factor-
[TNF- ], and -interferon [IFN- ]) initiate a variety of signal cascades in
pancreatic ß-cells that affect the expression level of genes involved in ... Cited by 61 - Related articles - BL Direct - All 4 versions
H Elouil, AK Cardozo, DL Eizirik, JC Henquin … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Hyperglycaemia and the pro- inflammatory cytokine
IL-1β induce similar alterations of beta cell gene expression, including
up-regulation of c-Myc and haeme-oxygenase 1. These effects of ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►nih.gov M Brownlee - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Diabetes and impaired glucose tolerance currently affect an estimated 29 million
people in the US (1). For those born in 2000, the estimated lifetime risk of
developing diabetes is 36% (2). People with diabetes have large reductions ... Cited by 100 - Related articles - BL Direct - All 10 versions
S Lenzen - Biochemical Society Transactions, 2008 - biochemsoctrans.org Antioxidative defence mechanisms of pancreatic β-cells are particularly weak
and can be overwhelmed by redox imbalance arising from overproduction of
reactive oxygen and reactive nitrogen species. The consequences of this ... Cited by 15 - Related articles - Cached - BL Direct - All 6 versions
LE Fridlyand, LH Philipson - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS)
production, and oxidative stress in pancreatic β-cells may be tightly linked
processes. Here we suggest that the same pathways used in the activation of ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org KLA Souza, E Gurgul-Convey, M Elsner, S … - Journal of Endocrinology, 2008 - Soc Endocrinology Pro-inflammatory cytokines cause β-cell dysfunction and death. The aim of this
study was to investigate the interactions between different pro- and
anti-inflammatory cytokines and their effects on apoptotic β-cell death ... Cited by 6 - Related articles - BL Direct - All 4 versions
D Lapenna, SD Pierdomenico, G Ciofani, MA … - Atherosclerosis, 2004 - Elsevier Little is known about the vascular metabolic status of glutathione (GSH), which
is crucial in cell antioxidant protection, in experimental conditions like
high-fat diet-induced atherosclerosis. This issue was, therefore, ... Cited by 10 - Related articles - All 7 versions
- ►endocrinology-journals.org [PDF] LA Sigfrid, JM Cunningham, N Beeharry, S … - Journal of molecular endocrinology, 2003 - Soc Endocrinology C Carlsson 2 and IC Green Pharmacy and Biomolecular Sciences, Cockcroft
Building, Room 708, University of Brighton, Lewes Road, Brighton BN2 4GJ, UK 1
Institute of Clinical Biochemistry, Hannover Medical School, D-30623 ... Cited by 13 - Related articles - BL Direct - All 5 versions
