Q Shi, D Wang, GA Hadley, AW Bingaman, ST … - Diabetes, 2004 - Am Diabetes Assoc Islet transplantation has great potential for curing type 1 diabetes; however,
long-term islet survival using conventional immunosuppression remains elusive.
We present a novel strategy for inducing long-lasting islet graft survival ... Cited by 10 - Related articles - BL Direct - All 6 versions
I Preda, RC McEvoy, M Lin, CA Bona, R … - European journal of immunology, 2005 - interscience.wiley.com Still there are no effective methods to predict or cure type 1 diabetes (T1D) in
humans. Soluble, dimeric MHC class II-peptide (DEF) chimeras have potential for
both early diagnosis and immunospecific therapy. DEF chimeras prevent and ... Cited by 4 - Related articles - BL Direct - All 3 versions
- ►asamnet.de [PDF] BA Herzog, PA Ott, MT Dittrich, S Quast, AY … - Journal of Autoimmunity, 2004 - Elsevier Active T cell recognition of islet antigens has been postulated as the
pathogenic mechanism in human type 1 diabetes, but evidence is scarce. If T
cells are engaged, they are expected to display increased clonal size and ... Cited by 7 - Related articles - All 5 versions
- ►diabetesjournals.org T Okitsu, N Kobayashi, HS Jun, S Shin, SJ … - Diabetes, 2004 - Am Diabetes Assoc Type 1 diabetes results from the destruction of insulin-producing pancreatic
β-cells by a β-cell–specific autoimmune process. Although converting other
cell types into insulin-producing cells may compensate for the loss of the ... Cited by 25 - Related articles - BL Direct - All 4 versions
JI Stagner, HL Rilo, KK White - JOP. J Pancreas (Online), 2007 - joplink.net Context The availability of islet transplantation is limited by both the number
of donor pancreata and the number of islets required for successful
transplantation. There is evidence that the liver presents a less than ... Cited by 8 - Related articles - Cached - All 3 versions
DM Waid, RJ Wagner, A Putnam, GM Vaitaitis … - Clinical Immunology, 2007 - Elsevier Human T1D pancreatic lymph nodes contain diabetes-autoantigen responsive T cells
but identification of such T cells in the periphery has proven difficult. Here
we describe a unique T cell subset defined by CD4 lo and CD40 expression (T ... Cited by 9 - Related articles - All 4 versions
P Van de Linde, PJM vd Boog, OMH Tysma, JF … - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov Pancreas transplantation in type 1 diabetes patients could result in
(re)activation of allo- and autoreactive T lymphocytes. Anti-thymocyte globulin
(ATG) induction treatment is a successful, but broadly reactive ... Cited by 9 - Related articles - BL Direct - All 5 versions
HS Jun, JW Yoon - Current gene therapy, 2005 - ingentaconnect.com Abstract: Type 1 diabetes results from insulin deficiency caused by autoimmune
destruction of insulin-producing pancre- atic β cells. Islet transplantation,
β cell regeneration, and insulin gene therapy have been explored in an ... Cited by 20 - Related articles - All 5 versions
MP Ndejembi, AL Tang, DL Farber - Clinical Immunology, 2007 - Elsevier Memory T cells are generated following an initial encounter with antigen,
persist over the lifetime of an individual, and mediate rapid and robust
functional responses upon antigenic recall. While immune memory is ... Cited by 10 - Related articles - All 5 versions
- ►shouxi.net JS Bromberg, D LeRoith - The New England journal of medicine, 2006 - nejm.highwire.org It is important to realize how far this field has come in the past few years
(Figure 1). Before 2000, the preceding two decades of islet transplantation had
achieved an international 1-year rate of allograft survival of less than ... Cited by 10 - Related articles - BL Direct - All 6 versions
