C Arden, A Harbottle, S Baltrusch, M Tiedge, L Agius - Diabetes, 2004 - Am Diabetes Assoc The association of glucokinase with insulin secretory granules has been shown by cell microscopy
techniques. We used MIN6 insulin-secretory cells and organelle fractionation to determine the
effects of glucose on the subcellular distribution of glucokinase. After permeabilization ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►endojournals.org S Baltrusch, S Langer, L Massa, M Tiedge, S Lenzen - Endocrinology, 2006 - Endocrine Soc The glucose sensor enzyme glucokinase plays a pivotal role in the regulation of glucose-induced
insulin secretion in pancreatic ß-cells. Activation of glucokinase represents a promising concept
for the treatment of type 2 diabetes. Therefore, we analyzed the glucokinase activation ... Cited by 8 - Related articles - BL Direct - All 4 versions
Y Toyoda, S Yoshie, H Shironoguchi, I Miwa - Histochemistry and cell biology, 1999 - Springer Glucokinase (GK; ATP: D -hexose 6-phosphotransferase, EC 2.7.1.1), often called hexokinase
IV, catalyzes the phosphorylation of glucose. It is distinguished from oth- er hexokinase isozymes
(types I–III) by its low affinity for glucose and lack of inhibition by glucose 6-phos- phate ( ... Cited by 25 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] M Stubbs, S Aiston, L Agius - Diabetes, 2000 - Am Diabetes Assoc We investigated the subcellular localization, mobility, and activity of glucokinase in MIN6
cells, a glucose- responsive insulin-secreting ß-cell line. Glucokinase is present in the cytoplasm
and a vesicular/granule com- partment that is partially colocalized with insulin gran- ules. ... Cited by 27 - Related articles - BL Direct - All 5 versions
A Shiraishi, Y Yamada, Y Tsuura, S Fijimoto, K … - Journal of Biological …, 2001 - ASBMB A glucokinase regulatory protein has been reported to exist in the liver, which suppresses enzyme
activity in a complex with fructose 6-phosphate, whereas no corresponding protein has been
found in pancreatic cells. To search for such a protein in pancreatic cells, we screened for ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►jbc.org MA Rizzo, MA Magnuson, PF Drain, DW Piston - Journal of Biological Chemistry, 2002 - ASBMB Glucokinase (GK) activity is essential for the physiological regulation of insulin secretion by
glucose. Because the enzyme exerts nearly total control over glucose metabolism in the
-cell, even small changes in GK activity exert effects on glucose-stimulated insulin ... Cited by 55 - Related articles - BL Direct - All 7 versions
S Baltrusch, S Lenzen, DA Okar, AJ Lange, M … - Journal of Biological …, 2001 - ASBMB The low affinity glucose-phosphorylating enzyme glucokinase shows the phenomenon of intracellular
translocation in beta cells of the pancreas and the liver. To identify potential binding partners
of glucokinase by a systematic strategy, human beta cell glucokinase was screened by a ... Cited by 5 - Related articles - All 2 versions
[CITATION] Interaction of PFK-2/FBPase-2 with glucokinase activated glucose phosphorylation …
C Vanhoutte, A Sener, WJ Malaisse - Molecular and cellular biochemistry, 1997 - Springer It was recently proposed that stimulation of pancreatic islet by D-glucose results in the translocation
of glucokinase from the perinuclear area to the cell periphery, where the enzyme might conceivably
interact with either the glucose transporter GLUT- 2 or some other proteins and, by doing ... Cited by 6 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org VA Payne, C Arden, C Wu, AJ Lange, L Agius - Diabetes, 2005 - Am Diabetes Assoc Hepatic glucokinase is regulated by a 68-kDa regulatory protein (GKRP) that is both an inhibitor
and nuclear receptor for glucokinase. We tested the role of 6-phosphofructo-2-kinase/fructose
-2,6-bisphosphatase (PFK2) in regulating glucokinase compartmentation in hepatocytes. ... Cited by 29 - Related articles - All 5 versions
