PK Mazumder, BT O'Neill, MW Roberts, J … - Diabetes, 2004 - Am Diabetes Assoc Diabetes alters cardiac substrate metabolism. The cardiac phenotype in
insulin-resistant states has not been comprehensively characterized. The goal of
these studies was to determine whether the hearts of leptin-deficient ... Cited by 99 - Related articles - BL Direct - All 6 versions
- ►endojournals.org J Buchanan, PK Mazumder, P Hu, G … - Endocrinology, 2005 - Endocrine Soc Hyperglycemia is associated with altered myocardial substrate use, a condition
that has been hypothesized to contribute to impaired cardiac performance. The
goals of this study were to determine whether changes in cardiac ... Cited by 69 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org S Boudina, S Sena, BT O'Neill, P Tathireddy, … - Circulation, 2005 - Am Heart Assoc Methods and Results— Cardiac function, M O 2 , mitochondrial respiration, and
ATP synthesis were measured in 9-week-old ob/ob and control mouse hearts.
Contractile function and M O 2 in glucose-perfused ob/ob hearts were ... Cited by 75 - Related articles - All 10 versions
- ►ahajournals.org LR Peterson, P Herrero, KB Schechtman, SB … - Circulation, 2004 - Am Heart Assoc Methods and Results— We studied 31 young women (body mass index [BMI] 19 to 52
kg/m 2 ); 19 were obese (BMI >30 kg/m 2 ). Myocardial oxygen consumption (M O 2
) and fatty acid uptake (MFAUp), utilization (MFAU), and oxidation (MFAO) ... Cited by 153 - Related articles - All 9 versions
AN Carley, DL Severson - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier The metabolic phenotype of hearts has been investigated using rodent models of
type 2 diabetes which exhibit obesity and insulin resistance: db/db and ob/ob
mice, and Zucker fatty and ZDF rats. In general, cardiac fatty acid (FA) ... Cited by 73 - Related articles - All 3 versions
- ►shouxi.net OJ How, E Aasum, DL Severson, WY Chan, … - Diabetes, 2006 - Am Diabetes Assoc Altered cardiac metabolism and function (diabetic cardiomyopathy) has been
observed in diabetes. We hypothesize that cardiac efficiency, the ratio of
cardiac work (pressure-volume area [PVA]) and myocardial oxygen consumption ... Cited by 58 - Related articles - BL Direct - All 5 versions
C Christoffersen, E Bollano, MLS Lindegaard, … - Endocrinology, 2003 - Endocrine Soc Obesity may confer cardiac dysfunction due to lipid accumulation in
cardiomyocytes. To test this idea, we examined whether obese ob/ob mice display
heart lipid accumulation and cardiac dysfunction. Ob/ob mouse hearts had ... Cited by 110 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org E Aasum, AD Hafstad, DL Severson, TS … - Diabetes, 2003 - Am Diabetes Assoc Glucose and palmitate metabolism and contractile function were measured with ex
vivo perfused working hearts from control (db/+) and diabetic (db/db) female
mice at 6, 10–12, and 16–18 weeks of age. Palmitate oxidation was ... Cited by 102 - Related articles - BL Direct - All 4 versions
- ►physiology.org P Wang, SG Lloyd, H Zeng, A Bonen, JC … - American Journal of Physiology- Heart and Circulatory …, 2005 - Am Physiological Soc The goal of this study was to determine whether changes in cardiac metabolism in
Type 2 diabetes are associated with contractile dysfunction or impaired response
to ischemia. Hearts from Zucker diabetic fatty (ZDF) and lean control rats ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►physiology.org AN Carley, LM Semeniuk, Y Shimoni, E Aasum … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Hearts from insulin-resistant type 2 diabetic db/db mice exhibit features of a
diabetic cardiomyopathy with altered metabolism of exogenous substrates and
reduced contractile performance. Therefore, the effect of chronic oral ... Cited by 59 - Related articles - BL Direct - All 5 versions
