Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell types when intracellular
glucose concentrations are high, and it can generate cellular stress through several
mechanisms. The role of the polyol pathway in the pathogenesis of diabetic retinopathy ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►pubget.com [PDF] IG Obrosova, AG Minchenko, R Vasupuram, L White, OI … - Diabetes, 2003 - Am Diabetes Assoc The study addressed the role for aldose reductase (AR) in 1) retinal oxidative stress and vascular
endothelial growth factor (VEGF) overexpression in early diabetes, and 2) high glucose-induced
oxidative stress in retinal endothelial cells. In vivo experiments were performed on control ... Cited by 83 - Related articles - BL Direct - All 5 versions
N Kato, S Yashima, T Suzuki, Y Nakayama, T … - Journal of Diabetes and its …, 2003 - Elsevier It is important to suppress retinal vascular changes for prevention of the onset and progression
of diabetic retinopathy. In the present study, we investigated the dose–response effect of an aldose
reductase (AR) inhibitor, fidarestat, on retinal vascular changes in the retinas of ... Cited by 32 - Related articles - All 8 versions
V Asnaghi, C Gerhardinger, T Hoehn, A Adeboje, M … - Diabetes, 2003 - Am Diabetes Assoc We tested the hypothesis that the apoptosis of inner retina neurons and increased expression
of glial fibrillary acidic protein (GFAP) observed in the rat after a short duration of diabetes are
mediated by polyol pathway activity. Rats with 10 weeks of streptozotocin-induced ... Cited by 105 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org AKH Cheung, MKL Fung, ACY Lo, TTL Lam, KF So, … - Diabetes, 2005 - Am Diabetes Assoc In 15-month-old db/db mice, signs of diabetic retinopathy, including blood-retinal barrier
breakdown, loss of pericytes, neuro-retinal apoptosis, glial reactivation, and proliferation of blood
vessels, were evident. These changes in the diabetic retina were associated with ... Cited by 50 - Related articles - BL Direct - All 5 versions
W Sun, C Gerhardinger, Z Dagher, T Hoehn, M Lorenzi - Diabetes, 2005 - Am Diabetes Assoc The prevention of diabetic retinopathy requires drugs that leverage the benefits of glycemic control
without adding the burden of side effects. Aspirin at dosages of 1–1.5 g/day has prevented manifestations
of diabetic retinal microangiopathy in a clinical trial as well as in studies with dogs. ... Cited by 24 - Related articles - BL Direct - All 6 versions
S Amano, S Yamagishi, N Kato, Y Inagaki, T … - … and Biophysical Research …, 2002 - Elsevier The polyol pathway consists of two enzymes, aldose reductase (AR) and sorbitol dehydrogenase
(SDH). There is a growing body of evidence to suggest that acceleration of the polyol pathway
is implicated in the pathogenesis of diabetic vascular complications. However, a ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C Gerhardinger, M … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical classes,
spirosuccinamide/hydantoins and carboxylic acids. Each class has its own drawbacks regarding
selectivity, in vivo potency, and human safety; as a result, the pathogenic role of aldose ... Cited by 38 - Related articles - BL Direct - All 7 versions
K Miwa, J Nakamura, Y Hamada, K Naruse, E … - Diabetes research and …, 2003 - Elsevier The pathogenesis of pericyte loss, an initial deficit in the early stage of diabetic retinopathy, remains
unclear. Recent studies have suggested that polyol pathway hyperactivity and apoptosis may
be involved in pericyte loss. The mechanisms of the glucose-induced apoptosis in retinal ... Cited by 37 - Related articles - All 7 versions
SSM Chung, SK Chung - Current Drug Targets, 2005 - ingentaconnect.com Abstract: Most long-term diabetic patients develop microvascular diseases such as
retinopathy, nephropathy and neuropathy. Although tight control of blood glucose greatly reduces
the incidence of these complications, a significant fraction of diabetic patients with good ... Cited by 38 - Related articles - All 2 versions
