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Scholar Results 1 - 10 of about 101 related to Li: Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels.... (0.19 sec) 

Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels …


H Li, DD Gutterman, NJ Rusch, A Bubolz, Y … - Diabetes, 2004 - Am Diabetes Assoc
Coronary microvessels generate reactive oxygen species in response to high
glucose (HG), resulting in vasodilator defects involving an impaired function of
vascular K + channels. Inhibition of voltage-gated K + (K v ) channels by ...
Cited by 30 - Related articles - BL Direct - All 5 versions

Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat …

- physiology.org
H Li, Q Chai, DD Gutterman, Y Liu - American Journal of Physiology- Heart and Circulatory …, 2003 - Am Physiological Soc
Hyperglycemia impairs endothelium-dependent vasodilation. In this study, we
examined the effect of high glucose (HG) on vascular smooth muscle function. Rat
small coronary arteries were freshly isolated or incubated for 24 h with ...
Cited by 25 - Related articles - BL Direct - All 3 versions

High glucose impairs voltage-gated K+ channel current in rat small coronary arteries

- ahajournals.org
Y Liu, K Terata, NJ Rusch, DD Gutterman - Circulation research, 2001 - Am Heart Assoc
Abstract—Hyperglycemia is associated with impaired endothelium-dependent
dilation that is due to quenching of NO by superoxide (O 2 · - ). In small
coronary arteries (CAs), dilation depends more on smooth muscle ...
Cited by 81 - Related articles - BL Direct - All 6 versions

Enhanced oxidative stress impairs cAMP-mediated dilation by reducing Kv channel function in …

- physiology.org
AH Bubolz, H Li, Q Wu, Y Liu - American Journal of Physiology- Heart and Circulatory …, 2005 - Am Physiological Soc
We have shown that short-term exposure of rat small coronary arteries (RSCAs) to
high glucose enhances superoxide (O 2 – ·) formation and impairs
cAMP-mediated dilation by reducing voltage-gated K + (K v ) channel ...
Cited by 12 - Related articles - BL Direct - All 4 versions

Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary …

- ahajournals.org
Y Liu, K Terata, Q Chai, H Li, LH Kleinman, … - Circulation research, 2002 - Am Heart Assoc
We examined the hypothesis that ONOO - , a product of the interaction between
superoxide (O 2 ·- ) and nitric oxide (NO), inhibits calcium-activated K + (K
Ca ) channel activity in vascular smooth muscle cells (VSMCs) of human ...
Cited by 78 - Related articles - BL Direct - All 9 versions

The highly conserved Glu149 and Tyr190 residues contribute to peroxynitrite-mediated …


H Lin, H Zhang, L Waskell, PF Hollenberg - Chem. Res. Toxicol, 2005 - pubs.acs.org
Tyr190 in cytochrome P450 2B1 has previously been shown to be a prime target for
nitration by peroxynitrite (PN) resulting in nitrotyrosine formation and the
inactivation of this enzyme. Modeling studies have suggested that Tyr190 ...
Cited by 11 - Related articles - All 4 versions

Peroxynitrite reversibly inhibits Ca2+-activated K+ channels in rat cerebral artery smooth …

- physiology.org
AK Brzezinska, D Gebremedhin, WM Chilian, B … - American Journal of Physiology- Heart and Circulatory …, 2000 - Am Physiological Soc
Peroxynitrite (ONOO ) is a contractile agonist of rat middle cerebral arteries.
To determine the mechanism responsible for this component of ONOO bioactivity,
the present study examined the effect of ONOO on ionic current and channel ...
Cited by 63 - Related articles - BL Direct - All 3 versions

Inhibitory effect of high concentration of glucose on relaxations to activation of ATP- …

- ahajournals.org
H Kinoshita, T Azma, K Nakahata, H Iranami, … - Arteriosclerosis, thrombosis, and vascular biology, 2004 - Am Heart Assoc
Methods and Results— Human omental arteries without endothelium were suspended
for isometric force recording. Changes in membrane potentials were recorded and
production of superoxide was evaluated. Glibenclamide abolished ...
Cited by 15 - Related articles - All 9 versions

Beta-adrenoceptor activation and PKA regulate delayed rectifier K+ channels of vascular …

- physiology.org
EA Aiello, AT Malcolm, MP Walsh, WC Cole - American Journal of Physiology- Heart and Circulatory …, 1998 - Am Physiological Soc
Macroscopic 4-aminopyridine (4-AP)-sensitive, delayed rectifier K + current of
vascular smooth muscle cells is increased during -adrenoceptor activation with
isoproterenol via a signal transduction pathway involving adenylyl cyclase ...
Cited by 46 - Related articles - BL Direct - All 3 versions

[CITATION] Group NDD (1995) Diabetes in America


LS Geiss, WH Herman, PJ Smith - Bethesda, MD: National Institutes of Health, National …
Cited by 3 - Related articles


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