E Suganami, H Takagi, H Ohashi, K Suzuma, I Suzuma … - Diabetes, 2004 - Am Diabetes Assoc Diabetic retinopathy is the leading cause of new blindness in adults in developed countries.
Leptin, an adipocyte-derived hormone, stimulates endothelial proliferation and
angiogenesis. This study was designed to elucidate the pathophysiologic role of leptin in ... Cited by 73 - Related articles - BL Direct - All 4 versions
X Jin, N Fukuda, J Su, H Takagi, Y Lai, Z Lin, K … - Atherosclerosis, 2003 - Elsevier The metabolic syndrome in association with obesity is a major clinical problem inducing
hypertension, diabetes mellitus, and atherosclerosis. Leptin induces angiogenesis by its proliferative
effects on endothelial cells (ECs) via OB receptor (OB-Rb) gene. We evaluated the growth ... Cited by 19 - Related articles - All 11 versions
- ►pnas.org R Cao, E Brakenhielm, C Wahlestedt, J … - Proceedings of the …, 2001 - National Acad Sciences Most endocrine hormones are produced in tissues and organs with permeable microvessels
that may provide an excess of hormones to be transported by the blood circulation to the distal
target organ. Here, we investigate whether leptin, an endocrine hormone, induces the ... Cited by 188 - Related articles - All 8 versions
J Mütze, J Roth, R Gerstberger, K Matsumura, T … - Neuroscience letters, 2006 - Elsevier Leptin binding to its functional receptor leads to activation of the JAK-STAT-signaling pathway
and especially to the activation of the signal transducer and activator of transcription factor 3
(STAT3). The immunohistochemical detection of nuclear STAT3 translocation is used as a ... Cited by 29 - Related articles - All 3 versions
- ►jbc.org RR Gonzalez, S Cherfils, M Escobar, JH Yoo, C … - Journal of Biological …, 2006 - ASBMB To gain insight into the mechanism(s) by which leptin contributes to mammary tumor (MT) development
we investigated the effects of leptin, kinase inhibitors, and/or leptin receptor antagonists
(LPrA2) on 4T1 mouse mammary cancer cells in vitro and LPrA2 on 4T1-MT development ... Cited by 28 - Related articles - BL Direct - All 5 versions
D Maberley, JZ Cui, JA Matsubara - Eye, 2005 - nature.com In patients with PDR (N=7), the average vitreous level of leptin (37.4 ng/ml) was significantly
higher than that in patients with PVR (<1.0 ng/ml, P<0.05). Vitreous leptin level in patients with
PVR or macular disease (N=18), with or without diabetes, was not significantly different ... Cited by 6 - Related articles - BL Direct - All 4 versions
B TURGUT, T DEMİR, S YILDIRIM … - Turkiye Klinikleri J …, 2004 - oftalmoloji.turkiyeklinikleri.com Proliferatif diyabetik retinopati, diskte ve reti- nanın di₣er bölgelerinde yeni damar olu umu, preretinal
ve vitreal hemorajilerin gözlendi₣i bir kliniktir. Diyabetik retinopatinin patogenezinde hipoksik
retinadan kaynaklanan vasküler endotelyal growth faktör (VGF), basic fibroblast growth ... Cited by 1 - Related articles - View as HTML - All 8 versions
FE Varzaneh, G Shillabeer, KL Wong, DC … - Metabolism: clinical and …, 1994 - ncbi.nlm.nih.gov 1: Metabolism. 1994 Jul;43(7):906-12. Extracellular matrix components secreted by microvascular
endothelial cells stimulate preadipocyte differentiation in vitro. Varzaneh FE, Shillabeer G, Wong
KL, Lau DC. Loeb Institute for Medical Research, Ottawa, Ontario, Canada. ... Cited by 58 - Related articles - BL Direct - All 2 versions
HY Park, HM Kwon, HJ Lim, BK Hong, JY Lee, … - … & molecular medicine, 2001 - ncbi.nlm.nih.gov Leptin, the product of ob gene, is an endocrine hormone that regulates adipose tissue mass.
Recently, leptin has been found to generate a growth signal involving a tyrosine kinase-dependent
intracellular pathway and promote angiogenic processes via activation of leptin receptor ... Cited by 243 - Related articles - BL Direct - All 11 versions
