- ►diabetesjournals.org LL Baggio, Q Huang, TJ Brown, DJ Drucker - Diabetes, 2004 - Am Diabetes Assoc Peptide hormones exert unique actions via specific G protein–coupled receptors; however, the
therapeutic potential of regulatory peptides is frequently compromised by rapid enzymatic inactivation
and clearance from the circulation. In contrast, recombinant or covalent coupling of ... Cited by 96 - Related articles - BL Direct - All 11 versions
JG Kim, LL Baggio, DP Bridon, JP Castaigne, MF … - Diabetes, 2003 - Am Diabetes Assoc The rapid degradation of native glucagon-like peptide 1 (GLP-1) by dipeptidyl peptidase-IV
(DPP-IV) has fostered new approaches for generation of degradation-resistant GLP-1
analogues. We examined the biological activity of CJC-1131, a DPP-IV-resistant drug ... Cited by 127 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org B Elbrønd, G Jakobsen, S Larsen, H Agersø, LB … - Diabetes Care, 2002 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—In a double-blind, randomized dose, escalation,
placebo-controlled study, healthy male subjects were enrolled at eight consecutive dose levels
(1.25, 2.5, 5.0, 10.0, 12.5, 15.0, 17.5, and 20.0 μg/kg) with eight subjects per dose level at ... Cited by 103 - Related articles - BL Direct - All 6 versions
BR Gedulin, P Smith, KS Prickett, M Tryon, S Barnhill, J … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 1380–1385 DOI 10.1007/s00125-005-1795-2 SHORT
COMMUNICATION BR Gedulin . P. Smith . KS Prickett . M. Tryon . S. Barnhill . J. Reynolds . LL
Nielsen . DG Parkes . AA Young Dose–response for glycaemic and metabolic changes 28 days ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Madsbad, O Schmitz, J Ranstam, G Jakobsen, … - Diabetes Care, 2004 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—A double-blind, randomized, parallel-group,
placebo-controlled trial with an open-label comparator arm was conducted among 193 outpatients
with type 2 diabetes. The mean age was 56.6 years and the mean HbA 1c was 7.6% ... Cited by 170 - Related articles - BL Direct - All 6 versions
R Gros, X You, LL Baggio, MG Kabir, AM Sadi, IN … - Endocrinology, 2003 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) acts via its G protein-coupled receptor (GLP-1R) to regulate
blood glucose. Although the GLP-1R is widely expressed in peripheral tissues, including the
heart, and exogenous GLP-1 administration increases heart rate and blood pressure in ... Cited by 60 - Related articles - BL Direct - All 7 versions
S Bregenholt, A Møldrup, N Blume, AE Karlsen, BN … - … and Biophysical Research …, 2005 - Elsevier We here show that GLP-1 and the long-acting GLP-1 analogue, liraglutide, interfere with
diabetes-associated apoptotic processes in the β-cell. Studies using primary neonatal rat islets
showed that native GLP-1 and liraglutide inhibited both cytokine- and free fatty ... Cited by 71 - Related articles - All 4 versions
- ►diabetesjournals.org KB Degn, CB Juhl, J Sturis, G Jakobsen, B Brock, V … - Diabetes, 2004 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1) is potentially a very attractive agent for treating type 2
diabetes. We explored the effect of short-term (1 week) treatment with a GLP-1 derivative, liraglutide
(NN2211), on 24-h dynamics in glycemia and circulating free fatty acids, islet cell ... Cited by 170 - Related articles - BL Direct - All 8 versions
- ►endojournals.org L Farilla, A Bulotta, B Hirshberg, S Li Calzi, N Khoury, H … - Endocrinology, 2003 - Endocrine Soc The peptide hormone, glucagon-like peptide 1 (GLP-1), has been shown to increase
glucose-dependent insulin secretion, enhance insulin gene transcription, expand islet cell
mass, and inhibit ß-cell apoptosis in animal models of diabetes. The aim of the present ... Cited by 218 - Related articles - BL Direct - All 5 versions
Y Li, T Hansotia, B Yusta, F Ris, PA Halban, DJ … - Journal of Biological …, 2003 - ASBMB Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion and augments β cell mass via activation
of β cell proliferation and islet neogenesis. We examined whether GLP-1 receptor signaling modifies
the cellular susceptibility to apoptosis. Mice administered streptozotocin (STZ), an agent ... Cited by 254 - Related articles - BL Direct - All 7 versions
