GJS Cooper, ARJ Phillips, SY Choong, BL Leonard, DJ … - Diabetes, 2004 - Am Diabetes Assoc Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia
and cardiovascular complications. Although altered systemic regulation of transition metals in
diabetes has been the subject of previous investigation, it is not known whether changed ... Cited by 49 - Related articles - BL Direct - All 8 versions
GJS Cooper, YK Chan, AM Dissanayake, FE Leahy, GF … - Diabetes, 2005 - Am Diabetes Assoc We recently showed that treatment with the Cu II -selective chelator, trientine, alleviates heart
failure in diabetic rats, improves left ventricular hypertrophy in humans with type 2 diabetes, and
increases urinary Cu excretion in both diabetic rats and humans compared with ... Cited by 28 - Related articles - All 9 versions
AA Young, CJ Occleshaw, YK Chan, FE … - …, 2004 - humannutritionunit.auckland.ac.nz Regeneration of the Heart in Diabetes by Selective Copper Chelation Garth JS Cooper; Anthony
RJ Phillips; Soon Y Choong; Bridget L Leonard; et al Diabetes; Sep 2004; 53, 9; Health & Medical
Complete pg. 2501 Regeneration of the Heart in Diabetes by Selective Copper Chelation ... Related articles - All 5 versions
- ►aspetjournals.org D Gong, J Lu, X Chen, SY Choong, S Zhang, YK Chan … - Molecular pharmacology, 2006 - ASPET Most patients with diabetes die from cardiac or arterial disease, for which there are limited therapeutic
options. Free Cu 2+ ions are strongly pro-oxidant, and chelatable-Cu II is increased in the diabetic
heart. We reported previously that treatment by Cu II -selective chelation with ... Cited by 10 - Related articles - All 6 versions
H Kodama, Y Murata, T Iitsuka, T Abe - Life Sciences, 1997 - Elsevier Triethylene tetramine dihydrochloride (trien 2HC1) has been used for the treatment of Wilson's
disease, which is characterized by the accumulation of copper in various organs. We previously
developed an HPLC system for analyzing trien, and found a trien metabolite in the urine ... Cited by 31 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org J Lu, YK Chan, GD Gamble, SD Poppitt, AA Othman, … - Drug Metabolism and …, 2007 - ASPET Triethylenetetramine (TETA), a selective Cu II -chelator used in the treatment of Wilson's
disease, is now undergoing clinical trials for the treatment of heart failure in diabetes. Despite
decades of clinical use, knowledge of its pharmacology in human subjects remains ... Cited by 8 - Related articles - BL Direct - All 6 versions
H KODAMA, Y MEGURO, A TSUNAKAWA, Y … - The Tohoku Journal of …, 1993 - Journal@rchive MURAKITA, H. Fate of Orally Administered Triethylenetetramine Dihydrochloride : A Therapeutic
Drug for Wilson's Disease. Tohoku J. Exp. Med., 1993, 169 (1), 59- 66 Triethylenetetramine dihydrochloride
(TETA) is a therapeutic drug for Wilson's disease. We developed a simple fluorometric ... Cited by 7 - Related articles - BL Direct - All 4 versions
A Keegan, MA Cotter, NE Cameron - Free Radical Biology and Medicine, 1999 - Elsevier Transition-metal catalyzed reactions contribute to oxidative stress, which has been implicated
in the pathogenesis of diabetic complications. The aim was to evaluate the effects of treatment
with the transition metal chelator trientine on endothelium-dependent relaxation of aorta ... Cited by 37 - Related articles - BL Direct - All 4 versions
AD Struthers, AD Morris - The Lancet, 2002 - Elsevier Patients with diabetes have an increased risk of cardiovascular morbidity and mortality. 1 In the
Framingham population, 2 risk of cardiovascular disease was doubled in men with diabetes
and tripled in women with the disease, even after adjustment for other risk factors such as ... Cited by 88 - Related articles - BL Direct - All 7 versions
A HortResearch, N Zealand - PROTEOMICS - interscience.wiley.com Cardiac disease is the commonest cause of death amongst diabetic patients. Diabetic
cardiomyopathy, which has a poor prognosis, is characterized by left ventricular hypertrophy
and impaired cardiac function and mitochondrial damage is said to contribute to its ... Cited by 5 - Related articles - BL Direct
