K Green, MD Brand, MP Murphy - Diabetes, 2004 - Am Diabetes Assoc Hyperglycemia causes many of the pathological consequences of both type 1 and type 2
diabetes. Much of this damage is suggested to be a consequence of elevated production of reactive
oxygen species by the mitochondrial respiratory chain during hyperglycemia. ... Cited by 145 - Related articles - BL Direct - All 8 versions
R Smith, G Kelso, F Blaikie, C Porteous, E … - Biochemical Society …, 2003 - bst.portlandpress.com The production of ROS (reactive oxygen species) by the mitochondrial respiratory chain contributes
to a range of pathologies, including neurodegenerative diseases, ischaemia/reperfusion injury
and aging. There are also indications that mitochondrial ROS production plays a role in ... Cited by 23 - Related articles - Cached - BL Direct - All 8 versions
RAJ Smith, GF Kelso, FH Blaikie, CM … - Biochemical Society …, 2003 - bst.portlandpress.com Abstract The production of ROS (reactive oxygen species) by the mitochondrial respiratory chain
contributes to a range of pathologies, including neurodegenerative diseases, ischaemia/reperfusion
injury and aging. There are also indications that mitochondrial ROS production plays a ... Related articles - View as HTML - All 4 versions
M Murphy - Biochemical Society Transactions, 2004 - bst.portlandpress.com A range of mitochondria-targeted probe molecules that comprise a lipophilic cation covalently
attached to an active moiety have been developed. The lipophilic cation causes the accumulation
of these molecules into mitochondria, driven by the mitochondrial membrane potential. To ... Cited by 9 - Related articles - Cached - BL Direct - All 8 versions
RAJ Smith, CM Porteous, AM Gane, MP … - Proceedings of the …, 2003 - National Acad Sciences Mitochondrial dysfunction contributes to many human degenerative diseases but specific treatments
are hampered by the difficulty of delivering bioactive molecules to mitochondria in vivo. To overcome
this problem we developed a strategy to target bioactive molecules to mitochondria by ... Cited by 108 - Related articles - BL Direct - All 8 versions
RAJ Smith, CM Porteous, CV Coulter, … - European Journal of …, 1999 - interscience.wiley.com Mitochondrial oxidative damage contributes significantly to a range of human disorders, including
neurodegenerative diseases, ischaemia-reperfusion injury and ageing-associated
dysfunction. To prevent this damage we have delivered a molecule containing the active ... Cited by 135 - Related articles - BL Direct - All 7 versions
AM James, MP Murphy - Journal of biomedical science, 2002 - Springer Abstract The pathophysiology of mitochondrial DNA (mtDNA) diseases is caused by increased
cell death and dysfunc- tion due to the accumulation of mutations to mtDNA. While the disruption
of oxidative phosphorylation is cen- tral to mtDNA diseases, many other factors, such as ... Cited by 62 - Related articles - BL Direct - All 7 versions
K Sakai, K Matsumoto, T Nishikawa, M Suefuji, K … - … and biophysical research …, 2003 - Elsevier Pancreatic β-cells exposed to hyperglycemia produce reactive oxygen species (ROS). Because
β-cells are sensitive to oxidative stress, excessive ROS may cause dysfunction of β-cells. Here
we demonstrate that mitochondrial ROS suppress glucose-induced insulin secretion ... Cited by 132 - Related articles - BL Direct - All 6 versions
MP Murphy - ebt, 2001 - informahealthcare.com Mitochondrial dysfunction causes or exacerbates a number of diseases. These include genetic
disorders such as Friedreich's ataxia where the primary lesion is a defect in a nuclear gene and
those diseases caused by mutations to mito- chondrial DNA. Mitochondrial damage also ... Cited by 42 - Related articles - All 4 versions
- ►nih.gov M Brownlee - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Diabetes and impaired glucose tolerance currently affect an estimated 29 million people in the
US (1). For those born in 2000, the estimated lifetime risk of developing diabetes is 36% (2).
People with diabetes have large reductions in life expectancy and in quality of life (2), due ... Cited by 102 - Related articles - BL Direct - All 10 versions
