- ►diabetesjournals.org CB Chan, MC Saleh, V Koshkin, MB Wheeler - Diabetes, 2004 - Am Diabetes Assoc Stressors such as chronic hyperglycemia or hyperlipidemia may lead to
insufficient insulin secretion in susceptible individuals, contributing to type
2 diabetes. The molecules mediating this effect are just beginning to be ... Cited by 84 - Related articles - BL Direct - All 4 versions
JW Joseph, V Koshkin, CY Zhang, J Wang, … - Diabetes, 2002 - Am Diabetes Assoc Uncoupling protein 2 (UCP2) may act as an important regulator of insulin
secretion. In this study, β-cell function in UCP2-deficient mice was examined
after a 45% high-fat diet (HFD) to assess its role during the development ... Cited by 119 - Related articles - BL Direct - All 5 versions
AV Medvedev, J Robidoux, X Bai, W Cao, LM … - Journal of Biological Chemistry, 2002 - ASBMB Current evidence suggests that uncoupling protein-2 (UCP2) is a regulator of
insulin secretion. It is also known that chronic exposure of pancreatic islets
to free fatty acids (FFAs) blunts glucose-stimulated insulin secretion and ... Cited by 75 - Related articles - BL Direct - All 5 versions
CB Chan, PE MacDonald, MC Saleh, DC Johns … - Diabetes, 1999 - Am Diabetes Assoc Uncoupling protein 2 (UCP-2) mRNA expression has been shown to be altered by
metabolic conditions such as obesity in humans, but its functional significance
is unknown. The expression of UCP-2 mRNA and protein in normal rat islets ... Cited by 164 - Related articles - BL Direct - All 6 versions
V Koshkin, X Wang, PE Scherer, CB Chan, … - Journal of Biological Chemistry, 2003 - ASBMB Excessive free fatty acid (FFA) exposure represents a potentially important
diabetogenic condition that can impair insulin secretion from pancreatic -cells.
Because mitochondrial oxidative phosphorylation is a main link between ... Cited by 64 - Related articles - BL Direct - All 5 versions
K Nadim, B Catherine, P Aristide, C Louis, P … - Experimental Diabetes Research, 1900 - hindawi.com Hypothesizing that UCP2 may influence insulin secretion by modifying the ATP/ADP
ratio within pancreatic islets, we have investigated the expression of
intraislet UCP2 gene in rats showing insulin oversecretion (non-diabetic ... Cited by 24 - Related articles - Cached - All 6 versions
- ►endojournals.org LX Li, F Skorpen, K Egeberg, IH Jorgensen, V … - Endocrinology, 2002 - Endocrine Soc A plausible theory on the functional importance of UCP-2 holds that regulation
of this protein provides a way to dissipate energy in situations of oversupply
to a specific tissue or cell (1, 2). Restraining the build-up of excessive ... Cited by 40 - Related articles - BL Direct - All 4 versions
JW Joseph, V Koshkin, MC Saleh, WI Sivitz, … - Journal of Biological Chemistry, 2004 - ASBMB Free fatty acid induced β-cell defects are dependent on ... Jamie W. Joseph 1
, Vasilij Koshkin 1 , Monique C. Saleh 3 , William I. Sivitz 2 , ... Chen-Yu
Zhang 4 , Bradford B. Lowell 4 , Catherine B. Chan 3 , Cited by 90 - Related articles - BL Direct - All 5 versions
MD'Adamo, L Perego, M Cardellini, MA Marini, S … - Diabetes, 2004 - Am Diabetes Assoc Uncoupling protein (UCP)-2 is a member of the mitochondrial inner membrane
carriers that uncouple pro-ton entry in the mitochondrial matrix from ATP
synthesis. The −866G/A polymorphism in the UCP2 gene, which enhances its ... Cited by 64 - Related articles - BL Direct - All 5 versions
MC Saleh, MB Wheeler, CB Chan - Diabetologia, 2002 - Springer Mitochondrial metabolism generates more than 90% of the ATP required byorganisms
for routine cellular processes. The efficiencyof ATP formation could be altered
bydemand, bydrugs or bypathological pro- cesses. Uncoupling agents ... Cited by 66 - Related articles - BL Direct - All 4 versions
