- ►diabetesjournals.org EH Leiter, PC Reifsnyder - Diabetes, 2004 - Am Diabetes Assoc The genetic basis for the more common forms of human obesity predisposing to
insulin resistance and development of type 2 diabetes is multigenic rather than
monogenic in origin. New mouse “diabesity” models have been created by ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org PC Reifsnyder, EH Leiter - Diabetes, 2002 - Am Diabetes Assoc Obesity-driven type 2 diabetes (diabesity) involves complex genetic and
environmental interactions to trigger disease. Here, we combine variable numbers
of known quantitative trait loci (QTL) for obesity and diabetes contributed ... Cited by 41 - Related articles - BL Direct - All 6 versions
- ►endojournals.org EH Leiter, PC Reifsnyder, W Zhang, H Pan, Q … - Endocrinology, 2006 - Endocrine Soc Polygenic mouse models for obesity-induced type 2 diabetes (T2D) more accurately
reflect the most common manifestations of the human disease. Two inbred mouse
strains (NON/Lt and NZO/HlLt) separately contributed T2D susceptibility- ... Cited by 14 - Related articles - BL Direct - All 5 versions
RA Koza, K Flurkey, DM Graunke, C Braun, HJ … - Metabolism, 2004 - Elsevier New Zealand Obese (NZO) male mice develop a polygenic juvenile-onset obesity and
maturity-onset hyperinsulinemia and hyperglycemia (diabesity). Here we report on
metabolic and molecular changes associated with the antidiabesity action of ... Cited by 14 - Related articles - All 12 versions
- ►physiology.org JH Kim, TP Stewart, W Zhang, HY Kim, PM … - Physiological Genomics, 2005 - Am Physiological Soc The TallyHo (TH) mouse strain is a polygenic model for Type 2 diabetes with
obesity. Genetic analysis in backcross progeny from a cross between F1 [C57BL/6J
(B6) x TH] and TH mice mapped a quantitative trait locus (QTL) named TH- ... Cited by 13 - Related articles - BL Direct - All 4 versions
H Ueda, H Ikegami, Y Kawaguchi, T Fujisawa … - Diabetologia, 2000 - Springer Type II (non-insulin-dependent) diabetes mellitus is a polygenic disease
characterised by insulin resis- tance in muscle, fat and liver, and the failure
of pan- creatic beta cells to adequately compensate for this Cited by 18 - Related articles - BL Direct - All 3 versions
- ►eje-online.org F Horio, S Teradaira, T Imamura, RVP … - European Journal of Endocrinology, 2005 - EFES Methods: Offspring from the cross between a wild male and a B6 female were
backcrossed to the sire. One male backcross which exhibited fasting
hyperglycemia was crossed with a B6 female to comprise the fundamental ... Cited by 3 - Related articles - BL Direct - All 7 versions
- ►oxfordjournals.org K Togawa, M Moritani, H Yaguchi, M Itakura - Human Molecular Genetics, 2006 - Oxford Univ Press Most quantitative trait loci (QTL) studies have focused on detecting the genetic
effects of individual QTLs. This study thoroughly dissected the genetic
components of type 2 diabetic mice, including a search for epistatic ... Cited by 13 - Related articles - BL Direct - All 7 versions
H Ikegami, T Fujisawa, T Ogihara - ILAR JOURNAL., 2004 - dels.nas.edu Except for rare subtypes of diabetes, both type 1 and type 2 diabetes are
multifactorial diseases in which genetic factors consisting of multiple
susceptibility genes and environmen- tal factors contribute to the disease ... Cited by 14 - Related articles - View as HTML - BL Direct - All 2 versions
- ►ucla.edu [PDF] RC Davis, EE Schadt, DJ Smith, EWY Hsieh, … - Genomics, 2005 - Elsevier In the analysis of complex traits, congenic strains are powerful tools because
they allow characterization of a single locus in the absence of genetic
variation throughout the remainder of the genome. Here, we report the ... Cited by 13 - Related articles - All 6 versions
