B Davani, N Portwood, G Bryzgalova, MK Reimer, T … - Diabetes, 2004 - Am Diabetes Assoc Glucocorticoids are diabetogenic hormones because they decrease glucose uptake, increase
hepatic glucose production, and inhibit insulin release. To study the long-term effects of increased
glucocorticoid sensitivity in β-cells, we studied transgenic mice overexpressing the rat ... Cited by 20 - Related articles - BL Direct - All 5 versions
S Gremlich, R Roduit, B Thorens - Journal of Biological Chemistry, 1997 - ASBMB GLUT2 expression is strongly decreased in glucose-unresponsive pancreatic β cells of diabetic
rodents. This decreased expression is due to circulating factors distinct from insulin or
glucose. Here we evaluated the effect of palmitic acid and the synthetic glucocorticoid ... Cited by 68 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] M Ohneda, JH Johnson, LR Inman, RH … - Journal of Clinical …, 1993 - pubmedcentral.nih.gov Spontaneous and dexamethasone-induced noninsulin-depen- dent diabetes mellitus
(NIDDM) in rats is associated with loss of glucose-stimulated insulin secretion (GSIS) and a reduction
in both GLUT-2-positive ftcells and high K. glucose transport. To determine if the ... Cited by 21 - Related articles - BL Direct - All 8 versions
S Ullrich, S Berchtold, F Ranta, G Seebohm, G Henke, … - Diabetes, 2005 - Am Diabetes Assoc Glucocorticoid excess predisposes to the development of diabetes, at least in part through impairment
of insulin secretion. The underlying mechanism has remained elusive. We show here that dexamethasone
upregulates transcription and expression of the serum- and glucocorticoid-inducible ... Cited by 50 - Related articles - All 5 versions
P Borboni, O Porzio, R Magnaterra, A Fusco, G … - Molecular and cellular …, 1996 - Elsevier Regulation of glucokinase (GK) gene expression in pancreatic β cells has been poorly
investigated, both due to low abundance of the gene and to difficulties in cells isolation. The
present study describes the establishment of a competitive RT-PCR method for ... Cited by 7 - Related articles - All 4 versions
A Khan, CG Ostenson, PO Berggren, S … - American Journal of …, 1992 - Am Physiological Soc GLUCOSE CYCLE (GC) is a futile cycle operating in liver and pancreatic islets (12, 13). The
cycle comprises the phosphorylation of glucose to glucose 6-phosphate and its simultaneous
dephosphorylation to glucose (12). The cycle, catalyzed by glucokinase and ... Cited by 26 - Related articles - BL Direct - All 3 versions
IK Jeong, SH Oh, BJ Kim, JH Chung, YK Min, MS … - Diabetes research and …, 2001 - Elsevier Complex results concerning the effect of glucocorticoids on insulin secretion have been
reported. The aim of this study is to clarify the direct effects of glucocorticoids on pancreatic islets
and to determine whether the effect of glucocorticoids on insulin biosynthesis or release ... Cited by 19 - Related articles - All 5 versions
D Hamamdzic, E Duzic, JD Sherlock, … - American Journal of …, 1995 - Am Physiological Soc Activation of az-adrenergic receptors &-AR> in pancreatic P-cells inhibits insulin secretion in
response to various stimuli, and acute or long-term regulation of (x2-AR receptor-mediated effects
may influence the tissue response to glucose dishomeo- stasis. As an initial approach to ... Cited by 22 - Related articles - BL Direct - All 3 versions
L Duplomb, Y Lee, MY Wang, BH Park, K Takaishi, … - … and Biophysical Research …, 2004 - Elsevier To determine if increased local production of glucocorticoids by the pancreatic islets might play
a role in the spontaneous noninsulin-dependent diabetes mellitus of obesity, we compared islet
11β-HSD-1 mRNA and activity in islets of obese prediabetic and diabetic Zucker Diabetic ... Cited by 21 - Related articles - All 5 versions
- ►nih.gov [PDF] C Lambillotte, P Gilon, JC Henquin - Journal of Clinical …, 1997 - pubmedcentral.nih.gov The direct effects of glucocorticoids on pancreatic cell function were studied with normal mouse
islets. Dexa- methasone inhibited insulin secretion from cultured islets in a concentration-dependent
manner: maximum of 75% at 250 nM and IC50 at 20 nM dexamethasone. This inhibi- tion ... Cited by 130 - Related articles - BL Direct - All 9 versions
