- ►diabetesjournals.org MC Sugden, MJ Holness - Diabetes, 2004 - Am Diabetes Assoc In this review, we discuss the influence of peroxisome proliferator-activated receptor
(PPAR)-α on islet insulin secretion and develop the hypothesis that modulation of PPAR-α function
may be important for the regulation of compensatory insulin secretion. We have attempted ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org [PDF] MJ Holness, ND Smith, GK Greenwood, MC … - Journal of …, 2003 - Soc Endocrinology Abnormal depletion or accumulation of islet lipid may be important for the development of pancreatic
cell failure. Long-term lipid sensing by cells may be co-ordinated via peroxisome
proliferator-activated receptors (PPARs). We investigated whether PPAR activation in vivo ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►jlr.org K Tordjman, KN Standley, C Bernal-Mizrachi, TC … - The Journal of Lipid …, 2002 - ASBMB Fatty acids may promote type 2 diabetes by altering insulin secretion from pancreatic ß cells,
a process known as lipotoxicity. The underlying mechanisms are poorly understood. To test the
hypothesis that peroxisome proliferator-activated receptor (PPAR ) has a direct effect on ... Cited by 68 - Related articles - BL Direct - All 5 versions
[CITATION] Acute (24 h) activation of peroxisome-proliferator-activated receptor (PPAR) a …
MC Sugden, K Bulmer, D Augustine, MJ Holness - Diabetes, 2001 - Am Diabetes Assoc The pyruvate dehydrogenase complex (PDC) has a pivotal role in islet metabolism. The pyruvate
dehydrogenase kinases (PDK1–4) regulate glucose oxidation through inhibitory phosphorylation
of PDC. Starvation increases islet PDK activity (Am J Physiol Endocrinol Metab 270:E988– ... Cited by 35 - Related articles - BL Direct - All 5 versions
H Yoshikawa, Y Tajiri, Y Sako, T Hashimoto, F Umeda, … - Metabolism, 2001 - Elsevier It is well known that acute administration of fatty acids enhances insulin release from β cells,
although chronic exposure to fatty acids inhibits insulin release (lipotoxicity). The mechanism
for these reciprocal effects of fatty acids on insulin release remains to be elucidated. The ... Cited by 54 - Related articles - BL Direct - All 7 versions
MJ MacDonald, A Kowluru - Molecular and Cellular Biochemistry, 1985 - Springer Pancreatic islet cytosol contains a calcium-calmodulin dependent protein kinase that can mediate
the phos- phorylation of an endogenous protein that has an Mr of 57 000, as well as exogenous
muscle pyruvate kinase (subunit Mr, 57000). EGTA and trifluoperazine decreased the ... Cited by 7 - Related articles - All 2 versions
MJ MacDonald, A Kowluru, CM Chang - Metabolism: clinical and …, 1985 - ncbi.nlm.nih.gov Rabbit pancreatic islet cytosol catalyzes the calcium-activated phosphorylation by [gamma
32P]ATP of a protein with a molecular weight of 57,000 that is precipitated with antipyruvate kinase
antibodies. We were unable to demonstrate that phosphorylation in the presence of ... Cited by 7 - Related articles - All 2 versions
- ►endojournals.org L Li, A Rojas, J Wu, C Jiang - Endocrinology, 2004 - Endocrine Soc The ATP-sensitive K + (K ATP ) channel, composed of Kir6.2 and sulfonylurea receptor
(SUR1), in pancreatic ß-cells is believed to serve as a metabolic sensor regulating insulin secretion
according to glucose levels. Thus, genetic disruption of Kir6.2 expression may impair K ... Cited by 7 - Related articles - BL Direct - All 5 versions
EH Koh, MS Kim, JY Park, HS Kim, JY Youn, HS Park, … - Diabetes, 2003 - Am Diabetes Assoc Lipid accumulation in nonadipose tissues is closely related to the development of type 2 diabetes
in obese subjects. We examined the potential preventive effect of peroxisome proliferator-activated
receptor (PPAR)-α and PPAR-γ stimulation on the development of diabetes in obese ... Cited by 104 - Related articles - BL Direct - All 6 versions
