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Scholar Results 1 - 10 of about 101 related to Bryan: Toward linking structure with function in ATP-sensitive K+ channels. (0.12 sec) 

Toward linking structure with function in ATP-sensitive K+ channels


J Bryan, WH Vila-Carriles, G Zhao, AP … - Diabetes, 2004 - Am Diabetes Assoc
Advances in understanding the overall structural features of inward rectifiers
and ATP-binding cassette (ABC) transporters are providing novel insight into the
architecture of ATP-sensitive K + channels (K ATP channels) (K IR 6.0/SUR) ...
Cited by 44 - Related articles - BL Direct - All 4 versions

N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel …


KW Chan, H Zhang, DE Logothetis - The EMBO Journal, 2003 - pubmedcentral.nih.gov
The sulfonylurea receptor (SUR), an ATP-binding cassette (ABC) protein,
assembles with a potassium channel subunit (Kir6) to form the ATP-sensitive
potassium channel (K ATP ) complex. Although SUR is an important regulator ...
Cited by 63 - Related articles - BL Direct - All 4 versions

Sur domains that associate with and gate KATP pores define a novel gatekeeper


AP Babenko, J Bryan - Journal of Biological Chemistry, 2003 - ASBMB
Structure-function analyses of K + channels identify a common pore architecture
whose gating depends on diverse signal sensing elements. The "gatekeepers" of
the long, ATP-inhibited K IR 6.0 pores of K ATP channels are ABC proteins, ...
Cited by 63 - Related articles - BL Direct - All 4 versions

The size of a single residue of the sulfonylurea receptor dictates the effectiveness of KATP …

- aspetjournals.org
C Moreau, F Gally, H Jacquet-Bouix, M … - Molecular pharmacology, 2005 - ASPET
K ATP channel openers are a diverse group of molecules able to activate
ATP-sensitive K + channels in a tissue-dependent manner by binding to the
channel regulatory subunit, the sulfonylurea receptor (SUR), an ATP-binding ...
Cited by 11 - Related articles - All 6 versions

SUR-dependent Modulation of KATP Channels by an N-terminal KIR 6. 2 Peptide. …


AP Babenko, J Bryan - Journal of Biological Chemistry, 2002 - ASBMB
Ntp and Ctp, synthetic peptides based on the N- and C-terminal sequences of K IR
6.0, respectively, were used to probe gating of K IR 6.0/SUR K ATP channels.
Micromolar Ntp dose-dependently increased the mean open channel probability ...
Cited by 33 - Related articles - BL Direct - All 4 versions

Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent …

- aspetjournals.org
M Yamada, M Ishii, H Hibino, Y Kurachi - Molecular pharmacology, 2004 - ASPET
The ATP-sensitive K + (K ATP ) channel is composed of a sulfonylurea receptor
(SUR) and a pore-forming subunit, Kir6.2. SUR is an ATP-binding cassette (ABC)
protein with two nucleotide-binding domains (NBD1 and NBD2). Intracellular ...
Cited by 15 - Related articles - BL Direct - All 6 versions

3-D structural and functional characterization of the purified KATP channel complex Kir6. 2 …


MV Mikhailov, JD Campbell, H de Wet, K … - The EMBO Journal, 2005 - pubmedcentral.nih.gov
ATP-sensitive potassium (K ATP ) channels conduct potassium ions across cell
membranes and thereby couple cellular energy metabolism to membrane electrical
activity. Here, we report the heterologous expression and purification of a ...
Cited by 51 - Related articles - BL Direct - All 5 versions

Assembly, maturation, and turnover of KATP channel subunits


A Crane, L Aguilar-Bryan - Journal of Biological Chemistry, 2004 - ASBMB
ATP-sensitive K + , or K ATP , channels are comprised of K IR 6.x and
sulfonylurea receptor (SUR) subunits that assemble as octamers, (K IR /SUR) 4 .
The assembly pathway is unknown. Pulse-labeling studies show that when K IR ...
Cited by 33 - Related articles - BL Direct - All 4 versions

Insulin secretagogues, sulfonylurea receptors and KATP channels


J Bryan, A Crane, WH Vila-Carriles, AP … - Current pharmaceutical design, 2005 - ingentaconnect.com
Abstract: ATP-sensitive K + channels, termed K ATP channels, provide a link
between cellular metabolism and membrane electrical activity in a variety of
tissues. Channel isoforms have been identified and are targets for ...
Cited by 38 - Related articles - BL Direct - All 4 versions

Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 …

- nih.gov [PDF] 
RD Rainbow, M James, D Hudman, M Al Johi, … - Biochemical Journal, 2004 - pubmedcentral.nih.gov
Biochem. J. (2004) 379, 173–181 (Printed in Great Britain) ... Proximal
C-terminal domain of sulphonylurea receptor 2A interacts with ... Richard D.
RAINBOW*, Marian JAMES†, Diane HUDMAN*, Mohammed AL JOHI†, Harprit ...
Cited by 10 - Related articles - BL Direct - All 10 versions


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