C Bleck, A Wienbergen, I Rustenbeck - Diabetes, 2004 - Am Diabetes Assoc The glucose dependence of the insulinotropic action of K ATP channel–blocking imidazoline
compounds was investigated. Administration of 100 μmol/l phentolamine, but not 100 μmol/l
efaroxan, markedly increased insulin secretion of freshly isolated mouse islets when the ... Cited by 9 - Related articles - BL Direct - All 5 versions
T GROSSE-LACKMANN, BJ ZÜNKLER, I … - Annals of the New …, 2003 - interscience.wiley.com Abstract: To characterize the specificity of nonadrenergic imidazoline binding sites of
insulin-secreting HIT cells, competitive binding of insulinotropic imidazolines and quinine was
measured and compared with the effect of these compounds on native K ATP channels ... Cited by 7 - Related articles - BL Direct - All 5 versions
I Rustenbeck, L Leupolt, R Kowalewski, A … - … archives of pharmacology, 1999 - Springer Abstract Imidazolines are regarded as a pharmacological group of insulin secretagogues with
one uniform mecha- nism of action, namely closure of ATP-dependent K ... Key words Imidazoline
compounds · Insulin secretion · Cytosolic calcium concentration · Plasma membrane ... Cited by 15 - Related articles - BL Direct - All 4 versions
C Bleck, A Wienbergen, I Rustenbeck - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Imidazolines are a class of investigational antidiabetic drugs. It is still
unclear whether the imidazoline ring is decisive for insulinotropic char- acteristics. Materials
and methods: We studied the imidazoline efaroxan and its imidazole analogue, KU14R, ... Cited by 9 - Related articles - BL Direct - All 4 versions
I Rustenbeck, C Dickel, T Grimmsmanns - Biochemical pharmacology, 2001 - Elsevier Prolonged in vitro exposure (18 h) of pancreatic islets to insulin secretagogues that block
ATP-dependent K + channels (K ATP channels), such as sulfonylureas, imidazolines, and
quinine, induced a desensitization of insulin secretion (Rustenbeck et al., pages ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►tu-bs.de [PDF] C Bleck - deposit.ddb.de Teilergebnisse aus dieser Arbeit wurden mit Genehmigung des Fachbereichs für Chemie und
Pharmazie, vertreten durch den Mentor der Arbeit, in folgenden Beiträgen vorab
veröffentlicht: ... BLECK C, WIENBERGEN A, RUSTENBECK I (2004): Glucose ... Cited by 2 - Related articles - All 4 versions
- ►nih.gov [PDF] SJ Ashcroft, PJ Randle - Proceedings of the Royal Society of …, 1968 - pubmedcentral.nih.gov MgHATPIr H+ + MgATP2- Since the avidity of MgATP2- formation is more than 100 times that
of MgHATP-, addition of Mg2+ to a mixture of HATP3- and ATP4- effec- tively increases its
ionization; that is, we move from left to right, with consequent liberation of H+. Conversely, ... Cited by 3 - Related articles - All 3 versions
G Mayer, PV Taberner - European Journal of Pharmacology, 2002 - Elsevier The putative imidazoline I 3 receptor antagonist 2-(2-ethyl-2,3-dihydrobenzo[b]furan-2-yl)-1H
-imidazole (KU14R) has been shown to block the effects of the atypical I 3 agonist efaroxan at
the level of the ATP-sensitive K + (K ATP ) channel in isolated pancreatic islet β cells, but ... Cited by 9 - Related articles - All 3 versions
AJ Ball, PR Flatt, NH McClenaghan - Pharmacological Research, 2000 - Elsevier The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize
imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations
of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell ... Cited by 9 - Related articles - BL Direct - All 4 versions
[CITATION] Synthesis and characterisation of KU14R a novel antagonist of the pancreatic islet …
