- ►diabetesjournals.org I Rustenbeck, A Wienbergen, C Bleck, A Jörns - Diabetes, 2004 - Am Diabetes Assoc Prolonged stimulation of insulin secretion by depolarization and Ca 2+ influx
regularly leads to a reversible state of decreased secretory responsiveness to
nutrient and nonnutrient stimuli. This state is termed "desensitization." ... Cited by 13 - Related articles - BL Direct - All 4 versions
I Rustenbeck, A Krautheim, A Jörns, HJ … - Biochemical pharmacology, 2004 - Elsevier A prolonged exposure of isolated pancreatic islets to insulin secretagogues, the
imidazolines phentolamine, alinidine and idazoxan (100 μM each), the
sulfonylurea tolbutamide (500 μM), or the alkaloid quinine (100 μM) ... Cited by 12 - Related articles - All 4 versions
C Bleck, A Wienbergen, I Rustenbeck - Diabetes, 2004 - Am Diabetes Assoc The glucose dependence of the insulinotropic action of K ATP channel–blocking
imidazoline compounds was investigated. Administration of 100 μmol/l
phentolamine, but not 100 μmol/l efaroxan, markedly increased insulin ... Cited by 9 - Related articles - BL Direct - All 5 versions
I Rustenbeck, C Dickel, T Grimmsmanns - Biochemical pharmacology, 2001 - Elsevier Prolonged in vitro exposure (18 h) of pancreatic islets to insulin secretagogues
that block ATP-dependent K + channels (K ATP channels), such as sulfonylureas,
imidazolines, and quinine, induced a desensitization of insulin secretion ( ... Cited by 9 - Related articles - BL Direct - All 5 versions
I Rustenbeck, L Leupolt, R Kowalewski, A … - Naunyn-Schmiedeberg's archives of pharmacology, 1999 - Springer Abstract Imidazolines are regarded as a pharmacological group of insulin
secretagogues with one uniform mecha- nism of action, namely closure of
ATP-dependent K ... Key words Imidazoline compounds · Insulin secretion ... Cited by 15 - Related articles - BL Direct - All 4 versions
I Rustenbeck - Biochemical pharmacology, 2002 - Elsevier Desensitization of insulin secretion describes a reversible state of decreased
secretory responsiveness of the pancreatic β-cell, induced by a prolonged
exposure to a multitude of stimuli. These include the main physiological ... Cited by 24 - Related articles - BL Direct - All 5 versions
M Høy, HL Olsen, HS Andersen, K Bokvist, K … - European journal of pharmacology, 2003 - Elsevier We have investigated the effects of the novel imidazoline compound (+)-2-(2-(4,5
-dihydro-1H-imidazol-2-yl)-thiopene-2-yl-ethyl)-pyridine (NNC77-0074) on
stimulus-secretion coupling in isolated pancreatic α- and β-cells. ... Cited by 17 - Related articles - All 5 versions
T GROSSE-LACKMANN, BJ ZÜNKLER, I … - Annals of the New York Academy of Sciences, 2003 - interscience.wiley.com Abstract: To characterize the specificity of nonadrenergic imidazoline binding
sites of insulin-secreting HIT cells, competitive binding of insulinotropic
imidazolines and quinine was measured and compared with the effect of these ... Cited by 7 - Related articles - BL Direct - All 5 versions
CJ Burns, SL Howell, PM Jones, SJ Persaud - Molecular and cellular endocrinology, 1999 - Elsevier The expression of the p38 subfamily of mitogen-activated protein kinases (MAPKs)
was examined in rat islets of Langerhans and pancreatic β-cell lines, and its
involvement in the regulation of insulin secretion was investigated. Rat ... Cited by 8 - Related articles - All 6 versions
- ►shouxi.net R Veluthakal, H Kaur, M Goalstone, A … - Diabetes, 2007 - Am Diabetes Assoc The majority of small G-proteins undergo posttranslational modifications (eg,
isoprenylation) at their C-terminal cysteine residues. Such modifications
increase their hydrophobicity, culminating in translocation of the modified ... Cited by 10 - Related articles - BL Direct - All 5 versions
