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Scholar Results 1 - 10 of about 101 related to Quast: The impact of ATP-sensitive K+ channel subtype selectivity of insulin secretagogues.... (0.11 sec) 

The impact of ATP-sensitive K+ channel subtype selectivity of insulin secretagogues for …

- diabetesjournals.org
U Quast, D Stephan, S Bieger, U Russ - Diabetes, 2004 - Am Diabetes Assoc
Insulin secretagogues (sulfonylureas and glinides) increase insulin secretion by
closing the ATP-sensitive K + channel (K ATP channel) in the pancreatic β-cell
membrane. K ATP channels subserve important functions also in the heart. ...
Cited by 61 - Related articles - BL Direct - All 4 versions

Is impairment of ischaemic preconditioning by sulfonylurea drugs clinically important?

- bmj.com
JJ Meier, B Gallwitz, WE Schmidt, A Mugge, … - British Medical Journal, 2004 - heart.bmj.com
ABSTRACT In the UGDP study, published in the 1970s, a high incidence of
cardiovascular mortality was found in patients treated with the sulfonylurea
agent tolbutamide. Impaired ischaemic preconditioning is presumed to be the ...
Cited by 47 - Related articles - BL Direct - All 7 versions

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either …

- ahajournals.org
MM Mocanu, HL Maddock, GF Baxter, CL … - Circulation, 2001 - Am Heart Assoc
Methods and Results—Rat hearts were Langendorff-perfused, subjected to 35
minutes of regional ischemia and 120 minutes of reperfusion, and assigned to 1
of the following treatment groups: (1) control; (2) IP of 2x 5 minutes each ...
Cited by 95 - Related articles - BL Direct - All 8 versions

Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes …


W Hueb, AH Uchida, BJ Gersh, RTB Betti, N … - Coronary artery disease, 2007 - journals.lww.com
Objective: Ischemic preconditioning is an increased tolerance to myocardial
ischemia during the second of two consecutive exercise tests. ATP-sensitive K +
channel blockers, such as glinides and sulfonylurea drugs, can induce loss ...
Cited by 10 - Related articles - BL Direct - All 3 versions

Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K …


D Stephan, M Winkler, P Kühner, U Russ, U … - Diabetologia, 2006 - Springer
Page 1. ARTICLE Selectivity of repaglinide and glibenclamide for the
pancreatic over the cardiovascular K ATP channels D. Stephan ...
Cited by 14 - Related articles - BL Direct - All 3 versions

Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus …

- canadianmedicaljournal.ca
SH Simpson, SR Majumdar, RT Tsuyuki, DT … - Canadian Medical Association Journal, 2006 - canadianmedicaljournal.ca
Methods: This was a retrospective, inception cohort study using administrative
data from Saskatchewan Health (1991– 1999). The 5795 subjects, identified by
their first-ever dispensation for an oral antidiabetic agent, were grouped ...
Cited by 74 - Related articles - BL Direct - All 11 versions

Sulfonylureas and cardiovascular effects: from experimental data to clinical use. Available …

- alfediam.org [PDF] 
JP Riveline, N Danchin, F Ledru, M Varroud- … - Diabetes and Metabolism, 2003 - Elsevier
The main molecule studied is glibenclamide (GB). In vitro and in animal studies,
GB is both deleterious for ischemic preconditionning (IPC) and protective for
arrhythmia during acute ischemia. Glimepiride (GM) and gliclazide (GCZ) do ...
Cited by 33 - Related articles - BL Direct - All 4 versions

6-Chloro-3-alkylamino-4H-thieno [3, 2-e]-1, 2, 4-thiadiazine 1, 1-Dioxide Derivatives …


FE Nielsen, TB Bodvarsdottir, A Worsaae, P … - J. Med. Chem, 2002 - pubs.acs.org
6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives
were synthesized and characterized as activators of adenosine 5'-triphosphate
(ATP) sensitive potassium (K ATP ) channels in the β-cells by measuring ...
Cited by 33 - Related articles - BL Direct - All 4 versions

Impairment of myocardial protection in type 2 diabetic patients

- endojournals.org
TM Lee, TF Chou - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc
EPIDEMIOLOGICAL STUDIES HAVE shown that diabetic patients are more prone to
develop postinfarction complications (1). Moreover, diabetic patients with
ischemic heart disease have a substantially worse outcome after coronary ...
Cited by 99 - Related articles - BL Direct - All 6 versions

Sulfonylurea stimulation of insulin secretion

- diabetesjournals.org
P Proks, F Reimann, N Green, F Gribble, F … - Diabetes, 2002 - Am Diabetes Assoc
Sulfonylureas are widely used to treat type 2 diabetes because they stimulate
insulin secretion from pancreatic ß-cells. They primarily act by binding to the
SUR subunit of the ATP-sensitive potassium (K ATP ) channel and inducing ...
Cited by 117 - Related articles - BL Direct - All 3 versions


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