- ►diabetesjournals.org GC Weir, S Bonner-Weir - Diabetes, 2004 - Am Diabetes Assoc This article proposes five stages in the progression of diabetes, each of which is characterized
by different changes in ß-cell mass, phenotype, and function. Stage 1 is compensation: insulin
secretion increases to maintain normoglycemia in the face of insulin resistance and/or ... Cited by 162 - Related articles - BL Direct - All 5 versions
DR Laybutt, M Glandt, G Xu, YB Ahn, N Trivedi, S … - Journal of Biological …, 2003 - ASBMB We have proposed that hyperglycemia-induced dedifferentiation of -cells is a critical factor for
the loss of insulin secretory function in diabetes. Here we examined the effects of the duration
of hyperglycemia on gene expression in islets of partially pancreatectomized (Px) rats. ... Cited by 69 - Related articles - BL Direct - All 4 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of both
Type 1 and Type 2 diabetes. This underlies the absolute or relative insu- lin insufficiency in both
conditions. In this For Debate, we consider the possible mechanisms responsible for beta- ... Cited by 123 - Related articles - BL Direct - All 6 versions
- ►sciencesignaling.org CJ Rhodes - Science Signaling, 2005 - sciencesignaling.org Abstract: In type 2 diabetes, the ß cells of the pancreas fail to produce enough insulin to meet
the body's demand, in part because of an acquired decrease in ß-cell mass. In adults, pancreatic
ß-cell mass is controlled by several mechanisms, including ß-cell replication, neogenesis, ... Cited by 287 - Related articles - All 13 versions
S Park, X Dong, TL Fisher, S Dunn, AK Omer, G … - Journal of Biological …, 2006 - ASBMB The insulin receptor substrate 2 (Irs2) branch of the insulin/insulin-like growth factor-signaling
cascade prevents diabetes in mice because it promotes β cell replication, function, and
survival, especially during metabolic stress. Because exendin-4 (Ex4), a long acting ... Cited by 65 - Related articles - BL Direct - All 8 versions
GC Weir - Seminars in Cell and Developmental Biology, 2004 - Elsevier Insufficient pancreatic β-cell mass is fundamental to the pathogenesis of both types 1 and 2 diabetes
and constitutes the basis for the goal of β-cell replacement therapy. Current methods for isolating
islets from organ donor pancreases do not come close to supplying all in need, thus ... Cited by 15 - Related articles - All 3 versions
- ►nih.gov AM Hennige, DJ Burks, U Ozcan, RN … - Journal of Clinical …, 2003 - Am Soc Clin Investig The insulin receptor substrate-2 (Irs2) branch of the insulin/IGF signaling system coordinates
peripheral insulin action and pancreatic β cell function, so mice lacking Irs2 display similarities
to humans with type 2 diabetes. Here we show that β cell–specific expression of Irs2 at a ... Cited by 132 - Related articles - BL Direct - All 10 versions
- ►nih.gov [PDF] YA Hosokawa, H Hosokawa, C Chen, … - Journal of Clinical …, 1996 - pubmedcentral.nih.gov Chronic hyperglycemia causes a near-total disappearance of glucose-induced insulin
secretion. To determine if glu- cose potentiation of nonglucose secretagogues is impaired, insulin
responses to 10 9 M glucagonlike peptide–1 (GLP-1) (7–37) were measured at 2.8, 8.3, ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►endojournals.org KH Yoon, SH Ko, JH Cho, JM Lee, YB Ahn, KH … - Journal of Clinical …, 2003 - Endocrine Soc In the presence of obesity, ß-cell mass needs to be increased to compensate for the accompanying
demands and maintain euglycemia. However, in Korea, the majority of type 2 diabetic patients
are nonobese. We determined the absolute masses, relative volumes, and ratio of - and ß- ... Cited by 179 - Related articles - BL Direct - All 4 versions
- ►physiology.org L Bouwens, I Rooman - Physiological reviews, 2005 - Am Physiological Soc Beta-cell mass regulation represents a critical issue for understanding diabetes, a disease characterized
by a near-absolute (type 1) or relative (type 2) deficiency in the number of pancreatic beta
cells. The number of islet beta cells present at birth is mainly generated by the ... Cited by 118 - Related articles - BL Direct - All 6 versions
