- ►diabetesjournals.org J Gromada, X Ma, M Høy, K Bokvist, A Salehi, PO … - Diabetes, 2004 - Am Diabetes Assoc Patch-clamp recordings and glucagon release measurements were combined to determine the
role of plasma membrane ATP-sensitive K + channels (K ATP channels) in the control of glucagon
secretion from mouse pancreatic α-cells. In wild-type mouse islets, glucose produced a ... Cited by 59 - Related articles - BL Direct - All 5 versions
YJ Liu, E Vieira, E Gylfe - Cell Calcium, 2004 - Elsevier The glucagon-releasing pancreatic α-cells are electrically excitable cells but the signal transduction
leading to depolarization and secretion is not well understood. To clarify the mechanisms we
studied [Ca 2+ ] i and membrane potential in individual mouse pancreatic α-cells using ... Cited by 38 - Related articles - All 3 versions
- ►endojournals.org HL Olsen, S Theander, K Bokvist, K Buschard, CB … - Endocrinology, 2005 - Endocrine Soc In isolated rat pancreatic -cells, glucose, arginine, and the sulfonylurea tolbutamide stimulated
glucagon release. The effect of glucose was abolished by the K ATP -channel opener diazoxide
as well as by mannoheptulose and azide, inhibitors of glycolysis and mitochondrial ... Cited by 43 - Related articles - BL Direct - All 5 versions
S Barg, J Galvanovskis, SO Gopel, P Rorsman, L … - Diabetes, 2000 - Am Diabetes Assoc -Cells were identified in preparations of dispersed mouse islets by immunofluorescence
microscopy. A high fraction of -cells correlated with a small cell size mea- sured as the average
cell diameter (10 µm) and whole-cell capacitance (<4 pF). The -cells generated action ... Cited by 82 - Related articles - BL Direct - All 4 versions
A Wendt, B Birnir, K Buschard, J Gromada, A Salehi, S … - Diabetes, 2004 - Am Diabetes Assoc Outside the CNS, GABA and GAD, the enzyme catalyzing the formation of the
neurotransmitter, are present at high levels in the pancreatic β-cells (2,3). GAD65 is the most
abundant, if not the only, isoform of GAD in human islets (4) and has been implicated in ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org MA Ravier, GA Rutter - Diabetes, 2005 - Am Diabetes Assoc The mechanisms by which hypoglycemia stimulates glucagon release are still poorly
understood. In particular, the relative importance of direct metabolic coupling versus paracrine
regulation by β-cell secretory products is unresolved. Here, we compare the responses to ... Cited by 66 - Related articles - All 5 versions
- ►physoc.org SO Gopel, T Kanno, S Barg, XG Weng, J … - The Journal of …, 2000 - Physiological Soc The perforated patch whole-cell configuration of the patch-clamp technique was applied to superficial
glucagon-secreting α-cells in intact mouse pancreatic islets. ... The T-type Ca 2+ , Na + and
A-currents were subject to steady-state voltage-dependent inactivation, which was half- ... Cited by 98 - Related articles - BL Direct - All 6 versions
I Franklin, J Gromada, A Gjinovci, S Theander, CB … - Diabetes, 2005 - Am Diabetes Assoc Glucagon, secreted from islet α-cells, mobilizes liver glucose. During hyperglycemia, glucagon
secretion is inhibited by paracrine factors from other islet cells, but in type 1 and type 2 diabetic
patients, this suppression is lost. We investigated the effects of β-cell secretory products ... Cited by 74 - Related articles - All 4 versions
S Göpel, Q Zhang, L Eliasson, XS Ma, J … - The Journal of …, 2004 - Physiological Soc Capacitance measurements of exocytosis were applied to functionally identified α-, β- and
δ-cells in intact mouse pancreatic islets. The maximum rate of capacitance increase in β-cells
during a depolarization to 0 mV was equivalent to 14 granules s −1 , <5% of that ... Cited by 52 - Related articles - All 7 versions
H Ishihara, P Maechler, A Gjinovci, PL Herrera, … - Nature Cell …, 2003 - medecine.unige.ch Homeostasis of blood glucose is maintained by hormone secretion from the pancreatic islets
of Langerhans. Glucose stimulates insulin secretion from β-cells but sup- presses the release
of glucagon, a hormone that raises blood glucose, from α-cells1. The mechanism by ... Cited by 146 - Related articles - BL Direct - All 4 versions
