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Scholar Results 1 - 10 of about 101 related to Holst: The incretin approach for diabetes treatment. (0.10 sec) 

The incretin approach for diabetes treatment


JJ Holst, C Ørskov - Diabetes, 2004 - Am Diabetes Assoc
Glucagon-like peptide (GLP)-1 is a gut hormone that stimulates insulin
secretion, gene expression, and ß-cell growth. Together with the related
hormone glucose-dependent insulinotropic polypeptide (GIP), it is ...
Cited by 45 - Related articles - BL Direct - All 4 versions

Therapeutic assessment of glucagon-like peptide-1 agonists compared with dipeptidyl …


R Mentlein - eid, 2005 - informahealthcare.com
The most prevalent form of diabetes is non-insulin-dependent or Type 2 dia-
betes. Innovative strategies to enhance insulin secretion and thereby improve
glucose tolerance in patients with this type of diabetes are currently ...
Cited by 13 - Related articles - BL Direct - All 6 versions

Glucagon-like peptide 1 (GLP-1) in the treatment of diabetes


MA Nauck - Hormone and Metabolic Research, 2004 - thieme-connect.com
Glucagon-like peptide 1 (GLP-1) was discovered as an incretin (insulinotropic
gut) hormone. Biological actions of GLP-1 in healthy and type 2 diabetic
subjects include (a) stimulation of insulin secretion in a ...
Cited by 38 - Related articles - All 5 versions

Incretins, insulin secretion and type 2 diabetes mellitus


T Vilsbøll, JJ Holst - Diabetologia, 2004 - Springer
When glucose is taken orally, insulin secretion is stim- ulated much more than
it is when glucose is infused intravenously so as to result in similar glucose
con- centrations. This effect, which is called the incretin ef- fect and is ...
Cited by 145 - Related articles - BL Direct - All 7 versions

Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV …


JJ Holst - emd, 2004 - informahealthcare.com
1. What is glucagon-like peptide-1? 2. Effects of glucagon-like peptide-1 3.
Glucagon-like peptide-1-based therapy of Type 2 diabetes mellitus 4. Expert
opinion and conclusion ... For reprint orders, please contact: ...
Cited by 50 - Related articles - All 6 versions

A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for …

- aspetjournals.org
N Irwin, BD Green, MH Mooney, B Greer, P … - Journal of Pharmacology and Experimental …, 2005 - ASPET
Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone
with a potentially therapeutic role in type 2 diabetes. Rapid degradation by
dipeptidylpeptidase IV has prompted the development of enzyme-resistant N- ...
Cited by 22 - Related articles - BL Direct - All 7 versions

Incretin hormones-an update


JJ Holst, C Orskov - Scandinavian Journal of Clinical and Laboratory …, 2001 - Informa Pharma Science
Incretin hormones are insulinotropic hormones from the intestinal mucosa, which
after being released in response to ingestion of a meal, enhance insulin
secretion in excess of that elicited by the absorbed nutrients (glucose, ...
Cited by 51 - Related articles - BL Direct - All 6 versions

Incretin hormones–an update


JJHC Ørskov - Scandinavian Journal of Clinical & Laboratory …, 2001 - informahealthcare.com
Incretin hormones are insulinotropic hormones from the intestinal mucosa, which
after being released in response to ingestion of a meal, enhance insulin
secretion in excess of that elicited by the absorbed nutrients (glucose, ...
Related articles

Type 2 diabetes—therapy with dipeptidyl peptidase IV inhibitors


HU Demuth, CHS McIntosh, RA Pederson - BBA-Proteins and Proteomics, 2005 - Elsevier
This was demonstrated in rat applying the specific DP IV inhibitor isoleucyl
thiazolidine. It was published in 1996 for the first time that a specific DP IV
inhibitor in a given dose was able to completely block glucagon-like ...
Cited by 79 - Related articles - All 3 versions

Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic …

- physiology.org
JJ Holst, J Gromada - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc
The available evidence suggests that about two-thirds of the insulin response to
an oral glucose load is due to the potentiating effect of gut-derived incretin
hormones. The strongest candidates for the incretin effect are ...
Cited by 180 - Related articles - BL Direct - All 4 versions


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