- ►diabetesjournals.org MS Winzell, B Ahrén - Diabetes, 2004 - Am Diabetes Assoc This study characterizes the high-fat diet–fed mouse as a model for impaired glucose tolerance
(IGT) and type 2 diabetes. Female C57BL/6J mice were fed a high-fat diet (58% energy by
fat) or a normal diet (11% fat). Body weight was higher in mice fed the high-fat diet ... Cited by 71 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org BF Burkey, X Li, L Bolognese, B Balkan, M Mone, M … - Journal of Pharmacology …, 2005 - ASPET The enzyme dipeptidyl peptidase-IV (DPP-4) inactivates the incretin hormone glucagon-like
peptide-1 (GLP-1). Because GLP-1 has therapeutic effects in patients with type 2 diabetes, but
its potential is limited by a short half-life, DPP-4 inhibition is a promising approach to ... Cited by 36 - Related articles - BL Direct - All 7 versions
- ►physiology.org B Ahren, G Pacini - American Journal of Physiology- …, 2002 - Am Physiological Soc This study evaluated the relative contribution of insulin-dependent mechanisms vs. mechanisms
independent on dynamic insulin for glucose intolerance induced by high-fat diet. C57BL/6J mice
underwent a frequently sampled intravenous glucose tolerance test (1 g/kg glucose) at 1 ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►physiology.org G Pacini, K Thomaseth, B Ahren - American Journal of Physiology …, 2001 - Am Physiological Soc To study the contributions of insulin-dependent vs. insulin-independent mechanisms to intravenous
glucose tolerance (K G ), 475 experiments in mice were performed. An intravenous glucose bolus
was given either alone or with exogenous insulin or with substances modulating insulin ... Cited by 64 - Related articles - BL Direct - All 4 versions
- ►eje-online.org [PDF] MK Reimer, JJ Holst, B Ahren - European Journal of Endocrinology, 2002 - EFES Objectives: Inhibitors of the glucagon-like peptide-1 (GLP-1)-degrading enzyme, dipeptidyl peptidase
IV (DPPIV), are being explored in the treatment of diabetes. We examined the long-term influence
of a selective, orally active inhibitor of DPPIV (NVP DPP728), in normal female C57BL/6J ... Cited by 107 - Related articles - BL Direct - All 9 versions
B Ahrén, E Simonsson, AJW Scheurink, H Mulder, U … - Metabolism, 1997 - Elsevier To study islet function following reduced insulin sensitivity, we examined mice of the C57BL/6J
strain, the genotype of which carries an increased propensity to develop insulin resistance when
metabolically challenged. The mice received either a high-fat diet (58% fat on an energy ... Cited by 69 - Related articles - BL Direct - All 5 versions
- ►cyut.edu.tw [PDF] K Srinivasan, B Viswanad, L Asrat, CL Kaul, P … - Pharmacological …, 2005 - Elsevier The objective of the present study was to develop a rat model that replicates the natural history
and metabolic characteristics of human type 2 diabetes and is also suitable for pharmacological
screening. Male Sprague–Dawley rats (160–180 g) were divided into two groups and fed ... Cited by 50 - Related articles - All 4 versions
H He, P Tran, H Yin, H Smith, Y Batard, L Wang, H … - Drug Metabolism and …, 2009 - ASPET The absorption, metabolism, and excretion of (1-[[3-hydroxy-1-adamantyl) amino]
acetyl]-2-cyano-(S)-pyrrolidine (vildagliptin), an orally active and highly selective dipeptidyl peptidase
4 inhibitor developed for the treatment of type 2 diabetes, were evaluated in four healthy ... Cited by 3 - Related articles - All 4 versions
- ►diabetesjournals.org T Hansotia, LL Baggio, D Delmeire, SA Hinke, Y … - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are
gut-derived incretins that potentiate glucose clearance following nutrient ingestion. Elimination
of incretin receptor action in GIPR −/− or GLP-1R −/− mice produces only modest ... Cited by 110 - Related articles - BL Direct - All 13 versions
[CITATION] Acute DPP IV inhibition minimizes glucose and insulin responses to a glucose …
