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Scholar Results 1 - 10 of about 101 related to Henquin: Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin.... (0.12 sec) 

Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin …

- diabetesjournals.org
JC Henquin - Diabetes, 2004 - Am Diabetes Assoc
Physiologically, insulin secretion is subject to a dual, hierarchal control by triggering and amplifying
pathways. By closing ATP-sensitive K + channels (K ATP channels) in the plasma
membrane, glucose and other metabolized nutrients depolarize β-cells, stimulate Ca 2+ ...
Cited by 37 - Related articles - BL Direct - All 4 versions

Both triggering and amplifying pathways contribute to fuel-induced insulin …

- jbc.org
M Nenquin, A Szollosi, L Aguilar-Bryan, J Bryan, JC … - Journal of Biological …, 2004 - ASBMB
In normal -cells glucose induces insulin secretion by activating both a triggering pathway (closure
of K ATP channels, depolarization, and rise in cytosolic [Ca 2+ ] i ) and an amplifying pathway
(augmentation of Ca 2+ efficacy on exocytosis). It is unclear if and how nutrients can ...
Cited by 44 - Related articles - BL Direct - All 5 versions

[CITATION] ves-Guerra MC, Goubern M, Surwit R, Bouillaud F, Richard D, Collins S, Ricquier D …


D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS … - Nat Genet, 2000
Cited by 3 - Related articles

[PDF] Alternative pathways of β-cell stimulation: possible therapeutic targets?


JC HENQUIN, B Brussels - MEDICOGRAPHIA, 2005 - medicographia.com
The pathogenesis of type 2 diabetes is complex, involving defects in both insulin secretion and
action. Therefore, treatment of the disease is usually multifactorial, associating lifestyle changes
(exercise, diet) and pharmacological approaches aimed at decreasing hepatic glucose ...
Related articles - View as HTML - All 2 versions

Subcellular distribution of hexokinase isoenzymes in pancreatic islet cells exposed …


C Vanhoutte, A Sener, WJ Malaisse - Molecular and cellular biochemistry, 1997 - Springer
It was recently proposed that stimulation of pancreatic islet by D-glucose results in the translocation
of glucokinase from the perinuclear area to the cell periphery, where the enzyme might conceivably
interact with either the glucose transporter GLUT- 2 or some other proteins and, by doing ...
Cited by 6 - Related articles - BL Direct - All 5 versions

Glucose-dependent increase in mitochondrial membrane potential, but not …

- physiology.org
E Heart, RF Corkey, JD Wikstrom, OS … - American Journal of …, 2006 - Am Physiological Soc
We examined the effects of different physiological concentrations of glucose on cytoplasmic Ca
2+ handling and mitochondrial membrane potential ( m ) and insulin secretion in single mouse
islet cells. The threshold for both glucose-induced changes in Ca 2+ and m ranged from 6 ...
Cited by 24 - Related articles - BL Direct - All 5 versions

Mitochondria consume energy and compromise cellular membrane potential by …


Y Takeda, MA Pérez-Pinzón, MD Ginsberg, TJ … - Journal of Cerebral Blood …, 2004 - nature.com
The direction of the chemical reaction of ATP synthetase is reversible. The present study was
designed to determine whether mitochondria produce or consume ATP during ischemia. For
this purpose, changes in mitochondrial membrane potential were measured in vivo at the ...
Cited by 9 - Related articles - BL Direct - All 7 versions

Functional heterogeneity of mitochondria after cardiac cold ischemia and …


AV Kuznetsov, S Schneeberger, O Renz, H … - Transplantation, 2004 - journals.lww.com
Background. Mitochondria play a critical role in ischemia-reperfusion injury of the heart. The
purpose of the present study was to analyze the intracellular region-specific functional state of
mitochondria after cold ischemia-reperfusion in a rat heart transplant model. Methods. ...
Cited by 9 - Related articles - BL Direct - All 4 versions

Toward linking structure with function in ATP-sensitive K+ channels


J Bryan, WH Vila-Carriles, G Zhao, AP Babenko, L … - Diabetes, 2004 - Am Diabetes Assoc
Advances in understanding the overall structural features of inward rectifiers and ATP-binding
cassette (ABC) transporters are providing novel insight into the architecture of ATP-sensitive
K + channels (K ATP channels) (K IR 6.0/SUR) 4 . The structure of the K IR pore has been ...
Cited by 44 - Related articles - BL Direct - All 4 versions

[CITATION] Hierarchy of the beta-cell signals controlling insulin secretion


JC Henquin, MA Ravier, M Nenquin, … - … Journal of Clinical …, 2003 - journals.indexcopernicus.com
logo IndexCopernicus, Current language: English. IC Journals Master List. Journal of the Week.
Journals Master List. Journals from CC list. Recently Added Journals. Top 100 Journals.
Publishers. Top 20 Publishers. Journal Search. Evaluation methodology. ...
Cited by 79 - Related articles - BL Direct - All 4 versions


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