- ►diabetesjournals.org T Shibasaki, Y Sunaga, S Seino - Diabetes, 2004 - Am Diabetes Assoc Intracellular ATP, cAMP, and Ca 2+ are major signals involved in the regulation of insulin secretion
in the pancreatic ß-cell. We recently found that the ATP-sensitive K + channel (K ATP
channel) as an ATP sensor, cAMP-GEFII as a cAMP sensor, Piccolo as a Ca 2+ sensor, ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►jbc.org T Shibasaki, Y Sunaga, K Fujimoto, Y Kashima, S … - Journal of Biological …, 2004 - ASBMB ATP, cAMP, and Ca 2+ are the major signals in the regulation of insulin granule exocytosis in
pancreatic cells. The sensors and regulators of these signals have been characterized
individually. The ATP-sensitive K + channel, acting as the ATP sensor, couples cell ... Cited by 50 - Related articles - BL Direct - All 4 versions
- ►physoc.org G Kang, OG Chepurny, B Malester, MJ … - The Journal of …, 2006 - Physiological Soc The Epac family of cAMP-regulated guanine nucleotide exchange factors (cAMPGEFs, also known
as Epac1 and Epac2) mediate stimulatory actions of the second messenger cAMP on insulin
secretion from pancreatic β cells. Because Epac2 is reported to interact in vitro with the ... Cited by 40 - Related articles - BL Direct - All 19 versions
H Hashiguchi, M Nakazaki, N Koriyama, M … - Diabetes/Metabolism … - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 10 - Related articles - All 3 versions
- ►physiology.org Y Miura, H Matsui - American Journal of Physiology- …, 2003 - Am Physiological Soc Glucagon-like peptide-1 (GLP-1) elevates the intracellular free calcium concentration ([Ca 2+
] i ) and insulin secretion in a Na + -dependent manner. To investigate a possible role of Na ion
in the action of GLP-1 on pancreatic islet cells, we measured the glucose-and GLP-1- ... Cited by 11 - Related articles - BL Direct - All 3 versions
[CITATION] Glucagon-like peptide-1 stimulates exocytosis in human pancreatic beta cells by …
EC Aromataris, ML Roberts, GJ Barritt, GY … - The Journal of …, 2006 - Physiological Soc Glucagon is one of the major hormonal regulators of glucose metabolism, counteracting the hepatic
effects of insulin when the concentration of glucose in the bloodstream falls below a certain
level. Glucagon also regulates bile flow, hepatocellular volume and membrane potential ... Cited by 14 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org M Nakazaki, A Crane, M Hu, V Seghers, S Ullrich, L … - Diabetes, 2002 - Am Diabetes Assoc Whereas the loss of ATP-sensitive K + channel (K ATP channel) activity in human pancreatic
β-cells causes severe hypoglycemia in certain forms of hyperinsulinemic hypoglycemia, similar
channel loss in sulfonylurea receptor-1 (SUR1) and Kir6.2 null mice yields a milder ... Cited by 53 - Related articles - BL Direct - All 5 versions
K Fujimoto, T Shibasaki, N Yokoi, Y Kashima, M … - Journal of Biological …, 2002 - ASBMB We have previously shown that cAMP-binding protein cAMP-guanidine nucleotide exchange
factor II (GEFII) (or Epac2) interacting with Rim2 is involved in cAMP-dependent, protein kinase
A-independent exocytosis in pancreatic β-cells. The action of the cAMP-GEFII·Rim2 ... Cited by 65 - Related articles - BL Direct - All 5 versions
MM Soundarapandian, D Wu, X Zhong, … - Journal of …, 2007 - interscience.wiley.com The Kir6.1 channels are a subtype of ATP-sensitive inwardly rectifying potassium (K ATP ) channels
that play an essential role in coupling the cell's metabolic events to electrical activity. In this
study, we show that functional Kir6.1 channels are located at excitatory pre-synaptic ... Cited by 5 - Related articles - BL Direct - All 4 versions
