H Kitano, K Oda, T Kimura, Y Matsuoka, M Csete, J … - Diabetes, 2004 - Am Diabetes Assoc The metabolic syndrome is a highly complex breakdown of normal physiology characterized
by obesity, insulin resistance, hyperlipidemia, and hypertension. Type 2 diabetes is a major manifestation
of this syndrome, although increased risk for cardiovascular disease (CVD) often ... Cited by 77 - Related articles - BL Direct - All 9 versions
H Kitano, K Oda - Molecular systems biology, 2006 - pubmedcentral.nih.gov The immune system provides organisms with robustness against pathogen threats, yet it also
often adversely affects the organism as in autoimmune diseases. Recently, the molecular interactions
involved in the immune system have been uncovered. At the same time, the role of the ... Cited by 41 - Related articles - BL Direct - All 5 versions
M Morohashi, AE Winn, MT Borisuk, H Bolouri, J … - Journal of theoretical …, 2002 - Elsevier Theory, experiment, and observation suggest that biochemical networks which are conserved
across species are robust to variations in concentrations and kinetic parameters. Here, we exploit
this expectation to propose an approach to model building and selection. We represent a ... Cited by 129 - Related articles - BL Direct - All 6 versions
R Tanaka, M Csete, J Doyle - IEE Proceedings-Systems Biology, 2005 - cds.caltech.edu Abstract: High-level, mathematically precise descriptions of the global organisation of complex
metabolic networks are necessary for understanding the global structure of metabolic
networks, the interpretation and integration of large amounts of biologic data (sequences, ... Cited by 21 - Related articles - View as HTML - BL Direct - All 5 versions
- ►cornell.edu [PDF] M Csete, J Doyle - TRENDS in Biotechnology, 2004 - Elsevier Systems biology is a multidisciplinary approach for describing, understanding and controlling
the properties and dynamics of whole biological networks and systems that combines high-throughput
data generation with new computational and mathematical tools [1]. The long-term goal in ... Cited by 130 - Related articles - All 8 versions
- ►129.173.33.56 [PDF] M Arita - Journal of biochemistry, 2005 - Jpn Biochemical Soc The notion of scale-freeness and its prevalence in both natural and artificial networks have recently
attracted much attention. The concept of scale-freeness is enthusiastically applied to almost any
conceivable network, usually with affirmative conclusions. Well-known scale-free ... Cited by 32 - Related articles - BL Direct - All 9 versions
H Kitano - Nature Reviews Genetics, 2004 - cogs.susx.ac.uk The discovery of fundamental, systems-level principles that underlie complex biological systems
is a prime sci- entific goal in systems biology1,2. Robustness is a prop- erty that allows a system
to maintain its functions despite external and internal perturbations. It is one of the fun- ... Cited by 395 - Related articles - BL Direct - All 23 versions
- ►matjazperc.com [PDF] M Marhl, M Perc, S Schuster - FEBS letters, 2005 - Elsevier We show by mathematical modelling that a two-level protein cascade can act as a band-pass
filter for time-limited oscillations. The band-pass filters are then combined into a network of
three-level signalling cascades that by filtering the frequency of time-limited oscillations ... Cited by 15 - Related articles - All 10 versions
H Kitano - Nature Reviews Cancer, 2004 - nature.com Cancers are extremely complex, heterogeneous diseases. Many approaches to anticancer treatment
have had limited success — cures are still rare. A fundamental hurdle to cancer therapy is acquired
tumour 'robustness'. The goal of this article is to present a perspective on cancer as a ... Cited by 125 - Related articles - BL Direct - All 3 versions
