I Leclerc, GA Rutter - Diabetes, 2004 - Am Diabetes Assoc Stimulation of AMP-activated protein kinase (AMPK) in skeletal muscle and liver is seen as an
exciting prospect for the treatment of type 2 diabetes. However, we have recently demonstrated
that changes in AMPK activity accompany the exposure of pancreatic islet β-cells to ... Cited by 28 - Related articles - BL Direct - All 5 versions
F Diraison, E Motakis, LE Parton, GP Nason, I Leclerc, … - Diabetes, 2004 - Am Diabetes Assoc Accumulation of triglyceride in islets may contribute to the loss of glucose-stimulated insulin secretion
(GSIS) in some forms of type 2 diabetes (Diraison et al., Biochem J 373:769–778, 2004).
Here, we use adenoviral vectors and oligonucleotide microarrays to determine the effects ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org SK Richards, LE Parton, I Leclerc, GA Rutter, … - Journal of …, 2005 - Soc Endocrinology Treatment of type 1 diabetes by islet transplantation is currently limited by loss of functional
ß-cell mass after transplantation. We investigated here whether adenovirus-mediated changes
in AMP-activated protein kinase (AMPK) activity, previously shown to affect insulin ... Cited by 45 - Related articles - BL Direct - All 6 versions
T Tsuboi, G da Silva Xavier, I Leclerc, GA Rutter - Journal of Biological …, 2003 - ASBMB Changes in 5'-AMP-activated protein kinase (AMPK) activity have recently been implicated in
the control of insulin secretion by glucose (da Silva Xavier, G., Leclerc, I., Varadi, A., Tsuboi,
T., Moule, SK, and Rutter, GA (2003) Biochem. J. 371, 761–774). Here, we examine the ... Cited by 54 - Related articles - BL Direct - All 4 versions
FAN ZHANG, A SJÖHOLM, Q ZHANG - Biochemical and biophysical research …, 2006 - cat.inist.fr We have studied acute effects of the PPARy agonist pioglitazone in vitro on human islets from
both non-diabetic and type 2 diabetic subjects. In 5 mM glucose, pioglitazone caused a transient
increase in insulin secretion in non-diabetic, but not diabetic, islets. Continuous presence ... Cited by 9 - Related articles - All 4 versions
X Wang, L Zhou, L Shao, L Qian, X Fu, G Li, T Luo, Y … - Life sciences, 2007 - Elsevier Changes in AMP-activated protein kinase (AMPK) activity contribute to the regulation of insulin
secretion. Troglitazone has been shown to lower serum insulin levels and protect beta cell
function. The aim of the present study was to examine the effects of troglitazone on AMPK ... Cited by 11 - Related articles - All 4 versions
G da Silva Xavier, I Leclerc, IP Salt, B … - Proceedings of the …, 2000 - National Acad Sciences Elevated glucose concentrations stimulate the transcription of the pre-proinsulin (PPI), L-type
pyruvate kinase (L-PK), and other genes in islet beta cells. In liver cells, pharmacological activation
by 5-amino-4-imidazolecarboxamide riboside (AICAR) of AMP-activated protein kinase ( ... Cited by 115 - Related articles - BL Direct - All 11 versions
- ►nih.gov [PDF] G da Silva Xavier, I Leclerc, A Varadi, T … - Biochemical …, 2003 - pubmedcentral.nih.gov AMP-activated protein kinase (AMPK) has recently been impli- cated in the control of preproinsulin
gene expression in pancreatic islet β-cells [da Silva Xavier, Leclerc, Salt, Doiron, Hardie, Kahn
and Rutter (2000) Proc. Natl. Acad. Sci. USA 97, 4023–4028]. Using pharmacological and ... Cited by 146 - Related articles - BL Direct - All 9 versions
- ►physiology.org I Leclerc, WW Woltersdorf, G da Silva … - American Journal of …, 2004 - Am Physiological Soc Metformin, a drug widely used in the treatment of type 2 diabetes, has recently been shown to
act on skeletal muscle and liver in part through the activation of AMP-activated protein kinase
(AMPK). Whether metformin or the satiety factor leptin, which also stimulates AMPK in ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►endojournals.org S Yamada, M Komatsu, Y Sato, K Yamauchi, I Kojima, … - Endocrinology, 2002 - Endocrine Soc Isolated rat islets were exposed to cAMP-elevating agents and/or nutrients. Insulin exocytosis
subsequently triggered by a depolarizing concentration of K + or a stimulatory concentration
of glucose was employed as an index of time-dependent potentiation (TDP). Stimulatory ... Cited by 11 - Related articles - BL Direct - All 4 versions
