F Diraison, E Motakis, LE Parton, GP Nason, I … - Diabetes, 2004 - Am Diabetes Assoc Accumulation of triglyceride in islets may contribute to the loss of
glucose-stimulated insulin secretion (GSIS) in some forms of type 2 diabetes
(Diraison et al., Biochem J 373:769–778, 2004). Here, we use adenoviral ... Cited by 21 - Related articles - BL Direct - All 4 versions
I Leclerc, GA Rutter - Diabetes, 2004 - Am Diabetes Assoc Stimulation of AMP-activated protein kinase (AMPK) in skeletal muscle and liver
is seen as an exciting prospect for the treatment of type 2 diabetes. However,
we have recently demonstrated that changes in AMPK activity accompany the ... Cited by 28 - Related articles - BL Direct - All 5 versions
X Wang, L Zhou, G Li, T Luo, Y Gu, L Qian, X Fu … - Biochemical and Biophysical Research …, 2007 - Elsevier AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. Changes in AMPK activity contribute to the regulation of insulin
secretion. Epidemiological evidence links the ingestion of saturated fatty ... Cited by 13 - Related articles - All 4 versions
- ►physiology.org I Leclerc, WW Woltersdorf, G da Silva Xavier, … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Metformin, a drug widely used in the treatment of type 2 diabetes, has recently
been shown to act on skeletal muscle and liver in part through the activation of
AMP-activated protein kinase (AMPK). Whether metformin or the satiety ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Eto, T Yamashita, J Matsui, Y Terauchi, M … - Diabetes, 2002 - Am Diabetes Assoc Triacylglyceride (TG) accumulation in pancreatic ß-cells is associated with
impaired insulin secretion, which is called lipotoxicity. To gain a better
understanding of the pathophysiology of lipotoxicity, we generated three ... Cited by 38 - Related articles - BL Direct - All 3 versions
FAN ZHANG, A SJÖHOLM, Q ZHANG - Biochemical and biophysical research communications( …, 2006 - cat.inist.fr We have studied acute effects of the PPARy agonist pioglitazone in vitro on
human islets from both non-diabetic and type 2 diabetic subjects. In 5 mM
glucose, pioglitazone caused a transient increase in insulin secretion in ... Cited by 9 - Related articles - All 4 versions
X Wang, L Zhou, L Shao, L Qian, X Fu, G Li, T … - Life sciences, 2007 - Elsevier Changes in AMP-activated protein kinase (AMPK) activity contribute to the
regulation of insulin secretion. Troglitazone has been shown to lower serum
insulin levels and protect beta cell function. The aim of the present study ... Cited by 11 - Related articles - All 4 versions
- ►endocrinology-journals.org SK Richards, LE Parton, I Leclerc, GA Rutter, … - Journal of Endocrinology, 2005 - Soc Endocrinology Treatment of type 1 diabetes by islet transplantation is currently limited by
loss of functional ß-cell mass after transplantation. We investigated here
whether adenovirus-mediated changes in AMP-activated protein kinase (AMPK) ... Cited by 44 - Related articles - BL Direct - All 6 versions
- ►endojournals.org S Yamada, M Komatsu, Y Sato, K Yamauchi, I … - Endocrinology, 2002 - Endocrine Soc Isolated rat islets were exposed to cAMP-elevating agents and/or nutrients.
Insulin exocytosis subsequently triggered by a depolarizing concentration of K +
or a stimulatory concentration of glucose was employed as an index of time- ... Cited by 11 - Related articles - BL Direct - All 4 versions
HK Nyblom, K Thorn, M Ahmed, P Bergsten - PROTEOMICS-Clinical Applications - interscience.wiley.com Extended hyperglycaemia leads to impaired glucose-stimulated insulin secretion
(GSIS) and eventually -cell apoptosis in individuals with type 2 diabetes
mellitus. In an attempt to dissect mechanisms behind the detrimental ... Cited by 11 - Related articles - BL Direct - All 4 versions
