- ►shouxi.net S Norlin, U Ahlgren, H Edlund - Diabetes, 2005 - Am Diabetes Assoc Glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells depends on
coordinated glucose uptake, oxidative metabolism, and Ca 2+ -triggered insulin
exocytosis. Impaired GSIS is a hallmark of type 2 diabetes. However, at ... Cited by 41 - Related articles - All 7 versions
- ►jbc.org EB Hammar, JC Irminger, K Rickenbach, G … - Journal of Biological Chemistry, 2005 - ASBMB Laminin-5-rich extracellular matrix derived from 804G cells (804G-ECM) engages 1
integrins to induce spreading, improve glucose-stimulated insulin secretion
(GSIS), and increase survival of pancreatic beta cells. The present study ... Cited by 39 - Related articles - BL Direct - All 5 versions
MS Baker, X Chen, XC Cao, DB Kaufman - Journal of Surgical Research, 2001 - Elsevier Background. Islet graft injury by cytokines released from inflammatory cells
(macrophages) that infiltrate the transplant site is an important mechanism of
early islet transplant dysfunction. This detrimental “cytokine effect” ... Cited by 43 - Related articles - BL Direct - All 12 versions
E Bernal-Mizrachi, W Wen, M Shornick, MA … - Diabetes, 2002 - Am Diabetes Assoc The purpose of the current study was to determine whether nuclear factor-κB
(NF-κB) activation is a component of the depolarization/Ca 2+ -dependent
signaling in β-cells. MIN6 cells were transfected with a plasmid ... Cited by 20 - Related articles - BL Direct - All 5 versions
I Chang, S Kim, JY Kim, N Cho, YH Kim, HS … - Diabetes, 2003 - Am Diabetes Assoc Recent studies incriminating tumor necrosis factor (TNF)- as the final effector
in pancreatic ß-cell death in type 1 diabetes underscore the potential role of
TNF- -dependent NF- B activation as an important modulator of pancreatic ... Cited by 46 - Related articles - BL Direct - All 5 versions
- ►nih.gov R Eldor, A Yeffet, K Baum, V Doviner, D Amar, … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences Type 1 diabetes is characterized by the infiltration of inflammatory cells into
pancreatic islets of Langerhans, followed by the selective and progressive
destruction of insulin-secreting beta cells. Islet-infiltrating leukocytes ... Cited by 50 - Related articles - BL Direct - All 8 versions
- ►jbc.org M Taoka, T Ichimura, A Wakamiya-Tsuruta, Y … - Journal of Biological Chemistry, 2003 - ASBMB V-1 is a 12-kDa protein consisting of three consecutive ANK repeats, which are
believed to serve as the surface for protein-protein interactions. It is thought
to have a role in neural development for its temporal profile of expression ... Cited by 36 - Related articles - BL Direct - All 4 versions
N Giannoukakis, WA Rudert, M Trucco, PD … - Journal of Biological Chemistry, 2000 - ASBMB Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that inhibits β cell
function and promotes Fas-triggered apoptosis. IL-1β is thought to act early in
the initiation of the autoimmune destruction of pancreatic β cells in type ... Cited by 127 - Related articles - BL Direct - All 4 versions
- ►pnas.org DM Schumann, K Maedler, I Franklin, D Konrad … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Pancreatic β cell mass and function increase in conditions of enhanced insulin
demand such as obesity. Failure to adapt leads to diabetes. The molecular
mechanisms controlling this adaptive process are unclear. Fas is a death ... Cited by 20 - Related articles - BL Direct - All 11 versions
A Kahn, 2005 - hal-descartes.archives-ouvertes.fr > Le génome des mammifères contient environ 26 000 gènes codant des pro-
téines, auxquels il faut ajouter quel- ques milliers de gènes dont l'action
est relayée par des micro-ARN. Les pre- miers d'entre eux furent ... Cited by 5 - Related articles - View as HTML - All 9 versions
