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Scholar Results 1 - 10 of about 101 related to Bose: Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. (0.09 sec) 

Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury

- shouxi.net
AK Bose, MM Mocanu, RD Carr, CL Brand, DM … - Diabetes, 2005 - Am Diabetes Assoc
Glucagon-like peptide 1 (GLP-1), a gut incretin hormone that stimulates insulin
secretion, also activates antiapoptotic signaling pathways such as
phosphoinositide 3-kinase and mitogen-activated protein kinase in ...
Cited by 102 - Related articles - All 12 versions

Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left …

- ahajournals.org
LA Nikolaidis, S Mankad, GG Sokos, G Miske, … - Circulation, 2004 - Am Heart Assoc
Methods and Results— We investigated the safety and efficacy of a 72-hour
infusion of GLP-1 (1.5 pmol/kg per minute) added to background therapy in 10
patients with AMI and LV ejection fraction (EF) <40% after successful ...
Cited by 149 - Related articles - BL Direct - All 7 versions

Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves …

- ahajournals.org
LA Nikolaidis, D Elahi, T Hentosz, A … - Circulation, 2004 - Am Heart Assoc
Background— The failing heart demonstrates a preference for glucose as its
metabolic substrate. Whether enhancing myocardial glucose uptake favorably
influences left ventricular (LV) contractile performance in heart failure ...
Cited by 103 - Related articles - BL Direct - All 6 versions

Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in …


T Zhao, P Parikh, S Bhashyam, H Bolukoglu, … - Science's STKE, 2006 - stke.sciencemag.org
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Cited by 30 - Related articles - BL Direct - All 6 versions

Cardiac function in mice lacking the glucagon-like peptide-1 receptor


R Gros, X You, LL Baggio, MG Kabir, AM Sadi … - Endocrinology, 2003 - Endocrine Soc
Glucagon-like peptide-1 (GLP-1) acts via its G protein-coupled receptor (GLP-1R)
to regulate blood glucose. Although the GLP-1R is widely expressed in peripheral
tissues, including the heart, and exogenous GLP-1 administration increases ...
Cited by 60 - Related articles - BL Direct - All 7 versions

Glucagon-Like Peptide 1 Protects the Heart From Injury: Results


H Effects, II Vivo, IV Models - members.medscape.com
In the in vivo preparation, mean arterial pressure and heart rate were recorded
throughout the experimental protocol. No statistically significant differences
between these values during stabilization, ischemia, or reperfusion were ...
Related articles - All 2 versions

Glucagon-Like Peptide 1 Protects the Heart From Injury: Research Design and Methods


IV Procedure, IH Preparation - members.medscape.com
Rats were anesthetized with midazolam (5 mg/ml), fentanyl (0.315 mg/ml), and
fluanisone (10 mg/ml) together with heparin (1 IU/kg) given by intraperitoneal
injection. Further doses of anesthetic were given intravenously as needed. ...
Related articles - All 2 versions

Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with …

- physiology.org
T Nystrom, MK Gutniak, Q Zhang, F Zhang, JJ … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc
GLP-1 stimulates insulin secretion, suppresses glucagon secretion, delays
gastric emptying, and inhibits small bowel motility, all actions contributing to
the anti-diabetogenic peptide effect. Endothelial dysfunction is strongly ...
Cited by 82 - Related articles - BL Direct - All 4 versions

Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and …

- aspetjournals.org
LA Nikolaidis, A Doverspike, T Hentosz, L … - Journal of Pharmacology and Experimental …, 2005 - ASPET
We have recently demonstrated the benefits of glucagon-like peptide-1 (GLP-1) in
enhancing regional and global myocardial function after reperfusion in the
clinical setting of acute myocardial infarction. We hypothesized that GLP-1 ...
Cited by 31 - Related articles - All 5 versions

Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional …


GG Sokos, LA Nikolaidis, S Mankad, D Elahi … - Journal of cardiac failure, 2006 - Elsevier
We investigated the safety and efficacy of a 5-week infusion of GLP-1 (2.5
pmol/kg/min) added to standard therapy in 12 patients with New York Heart
Association class III/IV heart failure and compared the results with those ...
Cited by 62 - Related articles - All 12 versions


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