- ►diabetesjournals.org S Boullu-Ciocca, A Dutour, V Guillaume, V Achard, C … - Diabetes, 2005 - Am Diabetes Assoc In humans, a hyperactivity of glucocorticoid metabolism was postulated to be involved in the
intrauterine programming of the metabolic syndrome in adulthood. We studied in rats the effects
of overfeeding, obtained by reducing the size of the litter in the immediate postnatal ... Cited by 50 - Related articles - All 5 versions
- ►eurodiabesity.org [PDF] M Lopez, LM Seoane, S Tovar, MC Garcia, R … - Diabetologia, 2005 - Springer Abstract Aim/hypothesis: Perinatal overfeeding predis- poses humans and rats to obesity and
diabetes in later life. One classical model for studying the effect of early feeding is manipulation
of the size of rat litters. Rats growing up in small litters gain more weight than rats growing ... Cited by 23 - Related articles - All 4 versions
A Plagemann, T Harder, A Rake, M Voits, H Fink, W … - Brain research, 1999 - Elsevier Overnutrition during critical developmental periods is suggested to be a risk factor for obesity
and associated metabolic disorders in later life. Underlying mechanisms are unknown. Neuropeptides
are essentially involved in the central nervous regulation of body weight. For instance, ... Cited by 130 - Related articles - All 4 versions
H Davidowa, A Plagemann - Neuroreport, 2000 - journals.lww.com Rats neonatally overnourished due to a reduced litter size develop persisting overweight throughout
life. A presumed mechanism leading to this 'malprogramming' consists of an acquired change
of the responsiveness to leptin of the neuronal system regulating feeding behavior. The ... Cited by 39 - Related articles - BL Direct - All 3 versions
H Davidowa, A Plagemann - Neuroreport, 2007 - journals.lww.com Rats exposed to early postnatal overfeeding by rearing in small litters become hyperphagic,
hyperleptinemic, and hyperinsulinemic throughout later life. Medial arcuate neurons are involved
in body weight regulation. They were tested in brain slices of control and small-litter rats ... Cited by 10 - Related articles - BL Direct - All 3 versions
A Plagemann, T Harder, A Rake, T Waas, … - Journal of …, 1999 - interscience.wiley.com Early postnatal overnutrition is a risk factor for obesity in juvenile and adult life. Underlying pathophysiological
mechanisms are still unclear. Hypothalamic neuropeptides are decisively involved in the regulation
of body weight and food intake. In this study, we investigated consequences of early ... Cited by 96 - Related articles - BL Direct - All 4 versions
S Boullu-Ciocca, O Paulmyer-Lacroix, F Fina, LH … - Obesity, 2003 - nature.com Research Methods and Procedures: Using quantitative reverse transcriptase-polymerase chain
reaction, we studied the expression of the GR mRNA isoforms (active, GR inactive, GR ) in circulating
mononuclear leukocytes (in which GR shares the same regulation with central nervous ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►weichenstellung-im-mutterleib.de [PDF] A Plagemann - Journal of perinatal medicine, 2004 - reference-global.com Alterations of the intrauterine and early postnatal nutri- tional, metabolic, and hormonal environment
may cause predispositions to the development of disorders and dis- eases in later life. Mechanisms
responsible for this peri- natally acquired 'malprogramming' still remain unclear. It has ... Cited by 53 - Related articles - BL Direct - All 8 versions
H Davidowa, T Ziska, A Plagemann - Neuroreport, 2004 - journals.lww.com Amylin and ghrelin are hormones produced, respectively, in pancreas and stomach. They have
a central action on food intake and body weight. Possible changes in their effect on hypothalamic
neuronal activity were investigated in overweight rats previously subjected to early ... Cited by 9 - Related articles - All 3 versions
- ►endojournals.org XQ Xiao, SM Williams, BE Grayson, MM Glavas, MA … - Endocrinology, 2007 - Endocrine Soc Excess weight gain during the early postnatal period increases the risk of persistent obesity into
adulthood and impacts on the subsequent risk for metabolic and cardiovascular diseases. The
current study investigated the long-term effect of early excess weight gain, through ... Cited by 10 - Related articles - BL Direct - All 4 versions
