- ►diabetesjournals.org Y Liu, Y Nakagawa, Y Wang, R Sakurai, PV Tripathi, K … - Diabetes, 2005 - Am Diabetes Assoc Excess tissue glucocorticoid action may contribute to the hyperglycemia and insulin resistance
associated with type 2 diabetes, but the associated mechanisms are poorly understood.
11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) converts inactive 11- ... Cited by 37 - Related articles - All 7 versions
C Opherk, F Tronche, C Kellendonk, D … - Molecular …, 2004 - Endocrine Soc Hepatic glucose production by gluconeogenesis is the main source of glucose during fasting
and contributes significantly to hyperglycemia in diabetes mellitus. Accordingly, glucose metabolism
is tightly controlled by a variety of hormones including insulin, epinephrine, glucagon, and ... Cited by 44 - Related articles - BL Direct - All 5 versions
M Jenson, G Kilroy, DA York, D Braymer - Obesity Research, 1996 - grande.nal.usda.gov Record Detail. Return to previous page, Save: Title: Abnormal regulation of hepatic
glucocorticoid receptor mRNA and receptor protein distribution in the obese Zucker rat.
Author: Jenson, M. : Kilroy, G. : York, DA : Braymer, D. Citation: Obes-res. ... Cited by 8 - Related articles - Cached - BL Direct - All 3 versions
AJ Drake, DEW Livingstone, R Andrew, JR Seckl, NM … - Endocrinology, 2005 - Endocrine Soc Altered peripheral glucocorticoid metabolism may be important in the pathogenesis of obesity
in humans and animal models. Genetically obese Zucker rats, Lep/ob mice, and obese humans
exhibit increased regeneration of active glucocorticoids selectively in adipose tissue by ... Cited by 28 - Related articles - All 5 versions
- ►endojournals.org Y Liu, C Yan, Y Wang, Y Nakagawa, N Nerio, A Anghel, … - Endocrinology, 2006 - Endocrine Soc The glucocorticoid receptor (GR) is a crucial target gene for glucocorticoid-induced insulin resistance
and hepatic gluconeogenesis linked to the development of type 2 diabetes. The liver X receptors
(LXRs) are nuclear receptors that play an important role in the regulation of the metabolic ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►nih.gov JM Paterson, NM Morton, C Fievet, CJ … - Proceedings of the …, 2004 - National Acad Sciences In obese humans and rodents there is increased expression of the key glucocorticoid (GC) regenerating
enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), in adipose tissue. This increased
expression appears to be of pathogenic importance because transgenic mice ... Cited by 144 - Related articles - BL Direct - All 10 versions
EE Kershaw, NM Morton, H Dhillon, L Ramage, JR … - Diabetes, 2005 - Am Diabetes Assoc Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11β-hydroxysteroid
dehydrogenases (11βHSDs). 11βHSD1 activates GCs, while 11βHSD2 inactivates GCs.
Adipocyte-specific amplification of GCs through transgenic overexpression of 11βHSD1 ... Cited by 82 - Related articles - All 6 versions
L Alberti, A Girola, L Gilardini, A Conti, S Cattaldo, … - International Journal of …, 2007 - nature.com The role of glucocorticoids production in adipose tissue in the development of metabolic disorders
in humans has not been fully characterized. We investigated whether in obese subjects, 11
-hydroxysteroid dehydrogenase type 1 (11 -HSD1) expression in subcutaneous (SAT) ... Cited by 14 - Related articles - BL Direct - All 4 versions
J Robitaille, C Brouillette, A Houde, JP Despres, A … - Obesity research, 2004 - cat.inist.fr Adipose tissue type 1 11 β-hydroxysteroid dehydrogenase(11 β-HSD 1), which generates hormonally
active cortisol from inactive cortisone, has been shown to play a central role in adipocyte differentiation
and abdominal obesity-related metabolic complications. The objective was to investigate ... Cited by 15 - Related articles - BL Direct - All 2 versions
- ►aspetjournals.org PB Jacobson, TW von Geldern, L Ohman, M … - Journal of Pharmacology …, 2005 - ASPET Glucocorticoids amplify endogenous glucose production in type 2 diabetes by increasing hepatic
glucose output. Systemic glucocorticoid blockade lowers glucose levels in type 2 diabetes, but
with several adverse consequences. It has been proposed, but never demonstrated, that ... Cited by 30 - Related articles - BL Direct - All 5 versions
