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Scholar Results 1 - 10 of about 101 related to Carrillo: Islet-infiltrating B-cells in nonobese diabetic mice predominantly target nervous.... (0.11 sec) 

Islet-infiltrating B-cells in nonobese diabetic mice predominantly target nervous …

- diabetesjournals.org
J Carrillo, MC Puertas, A Alba, RM Ampudia, X Pastor, … - Diabetes, 2005 - Am Diabetes Assoc
B-cells accumulate in pancreatic islets during the autoimmune response that precedes the onset
of type 1 diabetes. However, the role and antigenic specificity of these cells remain a
mystery. To elucidate the antigenic repertoire of islet-infiltrating B-cells in type 1 diabetes, ...
Cited by 14 - Related articles - All 6 versions

B cells in autoimmune diabetes


FS Wong, L Wen - The Review of Diabetic Studies, 2005 - pubmedcentral.nih.gov
Autoantibodies have been used as good markers for the prediction of future development of
type 1 diabetes mellitus (T1DM), but are not thought to be pathogenic in this disease. The role
of B cells that produce autoantibodies in the pathogenesis of human T1DM is largely ...
Cited by 8 - Related articles - All 6 versions

Targeting of pancreatic glia in type 1 diabetes


H Tsui, Y Chan, L Tang, S Winer, RK Cheung, G … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS— pSC cultures did not express major histocompatibility complex (MHC) class II and
were lysed by ex vivo CTLs from diabetic NOD mice. In vivo, restoration of MHC class I in
GFAP-β2m transgenics significantly accelerated adoptively transferred diabetes. Target ...
Cited by 4 - Related articles - BL Direct - All 4 versions

'Sensing'autoimmunity in type 1 diabetes

- cell.com
H Tsui, R Razavi, Y Chan, J Yantha, HM Dosch - Trends in Molecular Medicine, 2007 - Elsevier
Type 1 diabetes (T1D) results from autoimmune-mediated loss of insulin-producing β-cells. Recent
findings suggest that the events controlling T1D development are not only immunological, but
also neuronal in nature. In the non-obese diabetic (NOD) mouse model of T1D, a mutant ...
Cited by 8 - Related articles - All 4 versions

Phenotype and functional characteristics of islet-infiltrating B-cells suggest the …


MC Puertas, J Carrillo, X Pastor, RM Ampudia, A Alba, … - Diabetes, 2007 - Am Diabetes Assoc
B-cells participate in the autoimmune response that precedes the onset of type 1 diabetes, but
how these cells contribute to disease progression is unclear. In this study, we analyzed the phenotype
and functional characteristics of islet-infiltrating B-cells in the diabetes-prone NOD mouse ...
Cited by 1 - Related articles - BL Direct - All 6 versions

Murder mysteries in type 1 diabetes


DL Kaufman - Nature Medicine, 2003 - medscape.com
The islets are surrounded by a loose web of nerve fibers and a non-myelinating type of Schwann
cell, Schwann cells being the glial cells of the peripheral nervous system [5,6] . Before invading
the islets, immune cells accumulate outside the islet in close association with the ...
Cited by 10 - Related articles - BL Direct - All 4 versions

Specific inhibition of autoimmune T cell transmigration contributes to beta cell …

- jbc.org
AY Savinov, DV Rozanov, AY Strongin - Journal of Biological Chemistry, 2007 - ASBMB
Human diabetes mellitus (IDDM; type I diabetes) is a T cell-mediated disease that is closely modeled
in non-obese diabetic (NOD) mice. The pathogenesis of IDDM involves the transmigration of
autoimmune T cells into the pancreatic islets and the subsequent destruction of insulin- ...
Cited by 3 - Related articles - All 4 versions

Early, selective, and marked loss of sympathetic nerves from the islets of …


Q Mei, TO Mundinger, A Lernmark, GJ Taborsky - Diabetes, 2002 - Am Diabetes Assoc
To discover whether islet sympathetic nerves are damaged during the autoimmune destruction
of islet B-cells, we immunostained sections of pancreas from BioBreeder (BB) diabetic rats, using
antibodies against vesicular monoamine transporter 2 (VMAT2), a marker of sympathetic ...
Cited by 36 - Related articles - BL Direct - All 6 versions

Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis …


G Teitelman, Y Guz, S Ivkovic, M Ehrlich - Developmental … - interscience.wiley.com
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functional. We recommend using the latest version of Microsoft or Mozilla web browser to ...
Cited by 27 - Related articles - BL Direct - All 3 versions

Neuroinsular complex type I: morphology and frequency in lean and genetically …


S Persson-Sjögren - Pancreas, 2001 - journals.lww.com
No quantitative data are available regarding the rate of occurrence of nerve cells in association
with endocrine pancreas (ie, neuroinsular complexes type I [NICs]), or the difference in the distribution
of NICs in normal and diabetic pancreas. In this report, pancreata from 20-day, 7-week, ...
Cited by 12 - Related articles - BL Direct - All 5 versions


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