VB Ritov, EV Menshikova, J He, RE Ferrell, … - Diabetes, 2005 - Am Diabetes Assoc The current study addresses a novel hypothesis of subcellular distribution of
mitochondrial dysfunction in skeletal muscle in type 2 diabetes. Vastus
lateralis muscle was obtained by percutaneous biopsy from 11 volunteers ... Cited by 194 - Related articles - All 6 versions
DE Kelley, J He, EV Menshikova, VB Ritov - Diabetes, 2002 - Am Diabetes Assoc Skeletal muscle is strongly dependent on oxidative phosphorylation for energy
production. Because the insulin resistance of skeletal muscle in type 2 diabetes
and obesity entails dysregulation of the oxidation of both carbohydrate and ... Cited by 533 - Related articles - BL Direct - All 4 versions
- ►nih.gov K Morino, KF Petersen, S Dufour, D Befroy, J … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig To further explore the nature of the mitochondrial dysfunction and insulin
resistance that occur in the muscle of young, lean, normoglycemic,
insulin-resistant offspring of parents with type 2 diabetes (IR offspring), ... Cited by 165 - Related articles - BL Direct - All 10 versions
M Mogensen, K Sahlin, M Fernström, D … - Diabetes, 2007 - Am Diabetes Assoc We tested the hypothesis of a lower respiratory capacity per mitochondrion in
skeletal muscle of type 2 diabetic patients compared with obese subjects. Muscle
biopsies obtained from 10 obese type 2 diabetic and 8 obese nondiabetic ... Cited by 50 - Related articles - BL Direct - All 6 versions
KF Petersen, S Dufour, GI Shulman - PLoS Medicine, 2005 - medicine.plosjournals.org Rates of insulin-stimulated muscle mitochondrial ATP synthase flux and
insulin-stimulated increases in concentrations of intramyocellular inorganic
phosphate (P i ) were assessed by 31 P magnetic resonance spectroscopy ... Cited by 101 - Related articles - Cached - BL Direct - All 12 versions
- ►shouxi.net KF Petersen, S Dufour, D Befroy, R Garcia, … - The New England journal of medicine, 2004 - nejm.highwire.org Methods We performed hyperinsulinemic–euglycemic clamp studies in combination
with infusions of [6,6- 2 H 2 ]glucose in healthy, young, lean,
insulin-resistant offspring of patients with type 2 diabetes and insulin- ... Cited by 786 - Related articles - BL Direct - All 14 versions
- ►physiology.org JA Simoneau, DE Kelley - Journal of Applied Physiology, 1997 - Am Physiological Soc A GOOD DEAL OF THE FUNCTIONAL DIVERSITY of skeletal muscle derives from
differences of fiber type distribution, and this also helps determine metabolic
diversity of skeletal muscle. Insulin-stimulated metabolism in skeletal ... Cited by 171 - Related articles - BL Direct - All 5 versions
- ►nih.gov R Boushel, E Gnaiger, P Schjerling, M … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Insulin resistance and type 2 diabetes are associated
with mitochondrial dysfunction. The aim of the present study was to test the
hypothesis that oxidative phosphorylation and electron transport capacity ... Cited by 80 - Related articles - BL Direct - All 9 versions
CS Stump, KR Short, ML Bigelow, JM Schimke … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Mitochondria are the primary site of skeletal muscle fuel metabolism and ATP
production. Although insulin is a major regulator of fuel metabolism, its effect
on mitochondrial ATP production is not known. Here we report increases in ... Cited by 135 - Related articles - BL Direct - All 10 versions
- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, R … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and
pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable
abnormality is insulin resistance in skeletal muscle. Impaired ... Cited by 667 - Related articles - BL Direct - All 15 versions
