- ►shouxi.net S Lindley, CM Dayan, A Bishop, BO Roep, M … - Diabetes, 2005 - Am Diabetes Assoc Type 1 diabetes is a T-cell–mediated disease that is associated with loss of
immunological tolerance to self-antigens. The mechanisms involved in maintenance
of peripheral tolerance include a specialized subset of regulatory T-cells ... Cited by 290 - Related articles - All 5 versions
- ►diabetesjournals.org TM Brusko, CH Wasserfall, MJ Clare-Salzler, … - Diabetes, 2005 - Am Diabetes Assoc CD4 + CD25 + T-cells appear to play a crucial role in regulating the immune
response. Therefore, we evaluated the peripheral blood frequency and function of
CD4 + CD25 + T-cells in 70 type 1 diabetic patients and 37 healthy ... Cited by 108 - Related articles - All 5 versions
- ►rupress.org MA Kriegel, T Lohmann, C Gabler, N Blank, … - Journal of Experimental Medicine, 2004 - jem.rupress.org In autoimmune polyglandular syndromes (APS), several organ-specific autoimmune
diseases are clustered. Although APS type I is caused by loss of central
tolerance, the etiology of APS type II (APS-II) is currently unknown. ... Cited by 232 - Related articles - BL Direct - All 7 versions
AL Putnam, F Vendrame, F Dotta, PA Gottlieb - Journal of Autoimmunity, 2005 - Elsevier In mouse models, CD4 + CD25 + T cells are involved in maintenance of peripheral
tolerance. In humans, a subset of CD4 + CD25 + T cells expressing high levels of
CD25 (CD4 + CD25 high ) with characteristics identical to murine CD4 + CD25 ... Cited by 75 - Related articles - All 3 versions
- ►rupress.org V Viglietta, C Baecher-Allan, HL Weiner, DA … - Journal of Experimental Medicine, 2004 - jem.rupress.org CD4 + CD25 + regulatory T cells contribute to the maintenance of peripheral
tolerance by active suppression because their deletion causes spontaneous
autoimmune diseases in mice. Human CD4 + regulatory T cells expressing high ... Cited by 677 - Related articles - BL Direct - All 8 versions
- ►nih.gov A Kukreja, G Cost, J Marker, C Zhang, Z Sun, … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Susceptibility to immune-mediated diabetes (IMD) in humans and NOD mice involves
their inherently defective T cell immunoregulatory abilities. We have followed
natural killer (NK) T cell numbers in patients with IMD, both by flow ... Cited by 424 - Related articles - BL Direct - All 10 versions
- ►bloodjournal.org A Balandina, S Lecart, P Dartevelle, A Saoudi … - Blood, 2005 - Am Soc Hematology Thymus-derived CD4 + CD25 + regulatory T (Treg) cells are essential for the
maintenance of immunologic self-tolerance. Despite their critical role in the
active suppression of experimental autoimmune disorders, little is known ... Cited by 173 - Related articles - All 9 versions
- ►rupress.org MR Ehrenstein, JG Evans, A Singh, S Moore, … - Journal of Experimental Medicine, 2004 - jem.rupress.org Regulatory T cells have been clearly implicated in the control of disease in
murine models of autoimmunity. The paucity of data regarding the role of these
lymphocytes in human autoimmune disease has prompted us to examine their ... Cited by 449 - Related articles - BL Direct - All 9 versions
- ►rupress.org SM Pop, CP Wong, DA Culton, SH Clarke, R … - Journal of Experimental Medicine, 2005 - jem.rupress.org Natural CD4 + CD25 + regulatory T (CD4 + CD25 + T reg) cells play a key role in
the immunoregulation of autoimmunity. However, little is known about the
interactions between CD4 + CD25 + T reg cells and autoreactive T cells. ... Cited by 110 - Related articles - All 8 versions
- ►diabetesjournals.org T Brusko, C Wasserfall, K McGrail, R Schatz, … - Diabetes, 2007 - Am Diabetes Assoc Regulatory T-cells (Tregs) play a critical role in maintaining dominant
peripheral tolerance. Previous characterizations of Tregs in type 1 diabetes
have used antibodies against CD4 and α-chain of the interleukin-2 receptor ... Cited by 54 - Related articles - BL Direct - All 5 versions
